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Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Frontiers in Neuroscience

Nov 1, 2019

Jen-Hsiang T HsiaoWoojin Scott Kim

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Abstract

Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain popula...read more

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Adenosine Triphosphate
Brain
Cerebellum
Nerve Degeneration
Coenzyme Q10
Atrophic
Ubiquinone 7
Multiple System Atrophy
Pathogenesis
Parkinson's Disease and Parkinsonism
4
1
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Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Frontiers in Neuroscience

Nov 1, 2019

Jen-Hsiang T HsiaoWoojin Scott Kim

PMID: 31736705

DOI: 10.3389/fnins.2019.01187

Abstract

Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain popula...read more

Mentioned in this Paper

Adenosine Triphosphate
Brain
Cerebellum
Nerve Degeneration
Coenzyme Q10
4
1

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