Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Feng ChenChristopher B Eckman

Abstract

For millennia, ginseng and some of its components have been used to treat a wide variety of medical conditions, including age-related memory impairment. Because of its purported effects and apparently low rate of side effects, ginseng remains one of the top selling natural product remedies in the United States. Given its potential role for improving age-related memory impairments and its common use in China for the treatment of Alzheimer's disease-like symptoms, we analyzed the effects of commercially available preparations of ginseng on the accumulation of the Alzheimer's amyloid beta peptide (Abeta) in a cell-based model system. In this model system, ginseng treatment resulted in a significant reduction in the levels of Abeta in the conditioned medium. We next examined the effects of several compounds isolated from ginseng and found that certain ginsenosides lowered Abeta concentration in a dose-dependent manner with ginsenoside Rg3 having an approximate IC50 of under 25 microM against Abeta42. Furthermore, we found that three of these isolated components, ginsenoside Rg1, Rg3, and RE, resulted in significant reductions in the amount of Abeta detected in the brains of animals after single oral doses of these agents. The resul...Continue Reading

References

Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M RochT Saitoh
Sep 18, 1997·Journal of Neuropathology and Experimental Neurology·M C IrizarryB T Hyman
Oct 15, 1998·Alzheimer Disease and Associated Disorders·M OishiS Nakamura
Aug 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C R ColsonM E De Broe
Dec 14, 1999·European Journal of Clinical Pharmacology·B K VoglerE Ernst
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S J HaugabookC B Eckman
Jan 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·J L GoldP A Rochon
Jan 16, 2002·JAMA : the Journal of the American Medical Association·David W KaufmanAllen A Mitchell
Jul 18, 2002·Trends in Pharmacological Sciences·Diana Ines Dominguez, Bart De Strooper
Mar 19, 2003·Journal of Geriatric Psychiatry and Neurology·Eiichi KatadaKosei Ojika
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·David O Kennedy, Andrew B Scholey
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·D O KennedyH Ashton
Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
Aug 28, 2003·Lancet Neurology·Elio ScarpiniHoward Feldman
Dec 13, 2003·Neurobiology of Learning and Memory·Alexandra BourChantal Mathis
Mar 3, 2004·The American Journal of Chinese Medicine·V D PetkovV V Petkov
Mar 11, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chihiro TohdaKatsuko Komatsu
Jun 11, 2004·Advance Data·Patricia M BarnesRichard L Nahin
Apr 19, 2005·Archives of Pharmacal Research·Hai Ying BaoJong Seong Kang
Apr 27, 2005·Annals of Neurology·Xiao-Yuan LianJanet L Stringer
Jun 16, 2005·Neuro-Signals·Chihiro TohdaKatsuko Komatsu
Jun 25, 2005·Current Alzheimer Research·Eiichi KatadaRyuzo Ueda
Dec 27, 2005·Current Alzheimer Research·John Polich, Jody Corey-Bloom

❮ Previous
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Citations

Nov 29, 2007·Cellular and Molecular Neurobiology·Hai Yan Zhang, Xi Can Tang
Mar 26, 2010·Cellular and Molecular Neurobiology·Sung-Ok KimEunjoo H Lee
Feb 5, 2009·Neuromolecular Medicine·Albert Y SunGrace Y Sun
Mar 3, 2010·Molecular Neurobiology·Agnes SimonyiGrace Y Sun
Jun 27, 2008·Alzheimer Disease and Associated Disorders·Soon-Tae LeeManho Kim
Aug 8, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-H HeoM Kim
Jul 9, 2013·BMC Complementary and Alternative Medicine·Xiao-Hui ChangGuo-Zhu Han
Sep 19, 2012·Molecular Neurodegeneration·Samer O Abdul-HayMalcolm A Leissring
Nov 12, 2010·Alzheimer's Research & Therapy·Jinzhou TianYongyan Wang
Feb 19, 2016·BMC Complementary and Alternative Medicine·Jiyoung KimKi Won Lee
Jun 10, 2008·Expert Opinion on Emerging Drugs·Walter J Lukiw
May 30, 2013·Journal of Ginseng Research·Ik-Hyun Cho
Sep 10, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Min Fu, Ju-Tzu Li
Jul 30, 2011·Journal of Ethnopharmacology·Yuan LiuPengtao Li
Sep 12, 2015·Journal of Molecular Neuroscience : MN·Juanfang LiuGang Zhao
Dec 27, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jianling LiuLing Yang
Apr 23, 2014·Chinese Journal of Integrative Medicine·Jian-Guo WuBin Yu
Feb 11, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Naijing LiPing He
Oct 9, 2014·Annual Review of Pharmacology and Toxicology·Bart De Strooper, Lucía Chávez Gutiérrez
Aug 25, 2007·Pharmacology & Therapeutics·Mark A Findeis
Mar 20, 2016·American Journal of Alzheimer's Disease and Other Dementias·Ai-She GaoBin Lu
Mar 17, 2017·The Journal of Nutritional Biochemistry·Syed H OmarHassan K Obied
Jun 6, 2017·Drug Development and Industrial Pharmacy·Shaozhi ZhangQiu Yan
Dec 15, 2010·The Cochrane Database of Systematic Reviews·Jinsong GengReem Malouf
Jan 30, 2015·Laboratory animal research·Hak-Yong LeeMi-Kyung Pyo
Mar 21, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ki-Yeol Yoo, So-Young Park
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcello IritiFranco Faoro
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Edwin Sy ChanChristopher Chen
Oct 6, 2009·Biological & Pharmaceutical Bulletin·Jung-Hwa YangDong-Hyun Kim
Jul 8, 2020·Alzheimer's Research & Therapy·Caitlin N SuireMalcolm A Leissring

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