Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder

Biological Psychiatry
G RajkowskaL D Selemon

Abstract

Bipolar disorder (BPD) is a mental illness in which depression and mania typically alternate, and both phases can present with psychotic features. The symptomatology of BPD, therefore, resembles major depressive disorder (MDD) and schizophrenia (SCHZ), posing diagnostic dilemmas. Distinct alterations in cellular architecture of the dorsolateral prefrontal cortex distinguish SCHZ and MDD, whereas the cellular neuropathology of BPD has not been studied. Dorsolateral prefrontal area 9 was analyzed using a three-dimensional morphometric method in postmortem brains from 10 BPD patients and 11 matched nonpsychiatric control subjects. Area 9 in BPD was characterized by reduced neuronal density in layer III (16%-22%) and reduced pyramidal cell density in layers III and V (17%-30%). A 19% reduction in glial density was found in sublayer IIIc coupled with enlargement and changes in shape of glial nuclei spanning multiple layers. The morphologic signature of BPD, i.e., decreased neuronal and glial density in association with glial hypertrophy, is distinct from previously described elevations in neuronal density in SCHZ, instead resembling the reductions in cell density found in MDD. Thus, the neuropathologic distinctions between BPD and S...Continue Reading

References

Aug 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·M Baron, R S Gruen
Mar 1, 1989·Archives of General Psychiatry·L R BaxterR M Sumida
Oct 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenB Pakkenberg
Dec 15, 1988·The Journal of Comparative Neurology·R W Williams, P Rakic
Jul 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·M A Taylor, R Abrams
Jan 1, 1986·Archives of General Psychiatry·F M BenesE D Bird
Jan 1, 1991·The Journal of Neuropsychiatry and Clinical Neurosciences·G S FigielO Boyko
Jun 1, 1994·The American Journal of Psychiatry·T E SchlaepferG D Pearlson
Apr 1, 1993·Biological Psychiatry·S M StrakowskiA L Stoll
Feb 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·K F BermanD R Weinberger
May 1, 1996·Schizophrenia Research·A B Sereno, P S Holzman
Aug 29, 1997·Schizophrenia Research·R B ZipurskyR Katz
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·D OngürJ L Price
May 20, 1999·Biological Psychiatry·G RajkowskaC A Stockmeier
Jan 19, 2000·Schizophrenia Research·K O LimA Pfefferbaum
Mar 15, 2000·Biological Psychiatry·M E WinsbergT A Ketter
Nov 10, 2000·Lancet·G J MooreH K Menji
Dec 29, 2000·Molecular Psychiatry·H K ManjiG Chen
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Z U KhanP S Goldman-Rakic

❮ Previous
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Citations

Oct 12, 2007·Der Nervenarzt·N Müller, M J Schwarz
Jan 17, 2007·Psychopharmacology·Younglim LeeAnantha Shekhar
May 19, 2011·Psychopharmacology·Lorenzo Di Cesare MannelliCarla Ghelardini
Aug 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Hendrik BielauBruno Baumann
Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Tomas HajekMartin Alda
Oct 24, 2012·Current Psychiatry Reports·Gabriel Rodrigo FriesFlávio Kapczinski
Aug 9, 2005·Biological Psychiatry·Kiki ChangAllan L Reiss
May 15, 2002·Biological Psychiatry·Lynn D Selemon, Grazyna Rajkowska
Jul 13, 2002·Biological Psychiatry·Melissa P López-LarsonStephen M Strakowski
Jul 10, 2003·Journal of Psychiatric Research·Galila AgamGalit Shatiel
Jul 10, 2003·Journal of Psychiatric Research·José J Miguel-Hidalgo, Grazyna Rajkowska
Mar 12, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Timothy W CorsonJerry J Warsh
Oct 3, 2009·Psychological Medicine·W T CarpenterM J Green
Jul 9, 2008·Development and Psychopathology·David J Miklowitz, Kiki D Chang
Sep 6, 2002·Epidemiologia e psichiatria sociale·Paolo BrambillaJair Constante Soares
Apr 5, 2012·Molecular Psychiatry·K J BrennandF H Gage
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katie MahonPhilip R Szeszko
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Feb 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sujung J YoonPerry F Renshaw
Jun 10, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anita J Bechtholt-GompfBruce M Cohen
Apr 22, 2008·Nature Reviews. Drug Discovery·Gerard SanacoraHusseini K Manji
Jul 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohong SiGrazyna Rajkowska
Mar 10, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karl-Anton Dorph-PetersenDavid A Lewis
Oct 4, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert J SchloesserHusseini K Manji
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yogesh DwivediGhanshyam N Pandey
Dec 1, 2003·Acta Neuropsychiatrica·E Serap MonkulJair C Soares
Jul 30, 2004·The New England Journal of Medicine·R H Belmaker
Feb 6, 2009·Cerebral Cortex·Rebecca M ShanskyJohn H Morrison
Feb 9, 2010·Cerebral Cortex·Rebecca M ShanskyJohn H Morrison
Mar 9, 2011·Cerebral Cortex·Carrie E BeardenTyrone D Cannon
Sep 20, 2012·Cerebral Cortex·Shang-Feng GaoDick F Swaab
Apr 4, 2002·Neuroreport·Guoqiang XingRobert Post

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