Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors

Bioorganic & Medicinal Chemistry Letters
Felikss MutulisJarl E S Wikberg

Abstract

Presumed pharmacophoric groups of melanocortin peptides (naphthalene, amino or guanidine, and indole moieties) were combined in mimetics molecules looking for their favorable location for activity at melanocortin (MC) receptors. Twenty-two compounds were prepared and tested. The best of these displayed micromolar affinities for the MC receptors.

References

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Citations

May 25, 2005·Bioorganic & Medicinal Chemistry Letters·Xinrong TianRussell J Sheldon
Jun 5, 2003·Bioorganic & Medicinal Chemistry Letters·Christine G JosephCarrie Haskell-Luevano
Jul 10, 2003·Annals of the New York Academy of Sciences·J E S WikbergP Prusis
Mar 31, 2004·The Journal of Peptide Research : Official Journal of the American Peptide Society·A TodorovicC Haskell-Luevano
Jul 30, 2005·Peptides·Aleksandar Todorovic, Carrie Haskell-Luevano
Apr 21, 2005·European Journal of Pharmacology·Sergei KopanchukJarl E S Wikberg
Oct 13, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·C G JosephC Haskell-Luevano
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rodrigo AboniaSusana Zacchino
Mar 3, 2004·Medicinal Research Reviews·Jerry Ryan Holder, Carrie Haskell-Luevano

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