Reductive stress on life span extension in C. elegans.

BMC Research Notes
Markus Ralser, Ivor J Benjamin

Abstract

Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress' (Cell Metab 2007, 6: 280-293). Here, we suggest an alternative hypothesis that reductive stress can prevent calorie-restriction induced life span extension. We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants.

References

Dec 31, 2003·Experimental Gerontology·Hanyu LiangArlan Richardson
Feb 14, 2007·The Biochemical Journal·Nadine PollakMathias Ziegler
Jul 21, 2007·Free Radical Biology & Medicine·Florian L MullerHolly Van Remmen
Oct 30, 2007·Ageing Research Reviews·Suresh I S Rattan
Dec 25, 2007·Journal of Biology·Markus RalserSylvia Krobitsch

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Citations

Nov 20, 2010·Antioxidants & Redox Signaling·Edith LubosDiane E Handy
Nov 5, 2010·Diabetes, Obesity & Metabolism·D P Jones, Y-M Go
Jul 8, 2011·Basic & Clinical Pharmacology & Toxicology·Karolin YanarEzel Uslu
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Alicia J Kowaltowski
Jan 25, 2019·Current Pharmaceutical Design·B Poljsak, I Milisav
Jul 9, 2009·Physiological Reviews·Gregory R Steinberg, Bruce E Kemp
Oct 13, 2016·The Biochemical Journal·Ignacio AmigoAlicia J Kowaltowski
Jun 23, 2020·Oxidative Medicine and Cellular Longevity·Wei-Xing MaLiang-Jun Yan

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Methods Mentioned

BETA
protein folding

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