Redundancy in ribonucleotide excision repair: Competition, compensation, and cooperation

DNA Repair
Alexandra Vaisman, R Woodgate

Abstract

The survival of all living organisms is determined by their ability to reproduce, which in turn depends on accurate duplication of chromosomal DNA. In order to ensure the integrity of genome duplication, DNA polymerases are equipped with stringent mechanisms by which they select and insert correctly paired nucleotides with a deoxyribose sugar ring. However, this process is never 100% accurate. To fix occasional mistakes, cells have evolved highly sophisticated and often redundant mechanisms. A good example is mismatch repair (MMR), which corrects the majority of mispaired bases and which has been extensively studied for many years. On the contrary, pathways leading to the replacement of nucleotides with an incorrect sugar that is embedded in chromosomal DNA have only recently attracted significant attention. This review describes progress made during the last few years in understanding such pathways in both prokaryotes and eukaryotes. Genetic studies in Escherichia coli and Saccharomyces cerevisiae demonstrated that MMR has the capacity to replace errant ribonucleotides, but only when the base is mispaired. In contrast, the major evolutionarily conserved ribonucleotide repair pathway initiated by the ribonuclease activity of ty...Continue Reading

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Citations

Nov 1, 2015·Nucleic Acids Research·Nicholas C BauerPaul W Doetsch
Mar 24, 2016·Nucleic Acids Research·Sonoko IshinoYoshizumi Ishino
Jul 5, 2018·Critical Reviews in Biochemistry and Molecular Biology·Alexandra Vaisman, Roger Woodgate
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Aug 9, 2020·Nature Reviews. Genetics·Dali ZongAndré Nussenzweig
May 1, 2021·Cells·María Moreno-Del ÁlamoJuan Carlos Alonso

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