Redundancy, phylogeny and differential expression of Histoplasma capsulatum catalases

Microbiology
Clayton H JohnsonJoan E McEwen

Abstract

Histoplasma capsulatum produces an extracellular catalase termed M antigen, which is similar to catalase B of Aspergillus and Emericella species. Evidence is presented here for two additional catalase isozymes in H. capsulatum. Catalase A is highly similar to a large-subunit catalase in Aspergillus and Emericella species, while catalase P is a small-subunit catalase protein with greatest similarity to known peroxisomal catalases of animals and Saccharomycotina yeasts. Complete cDNAs for the CATA and CATP genes (encoding catalases A and P, respectively) were isolated. The transcriptional expression of the H. capsulatum CATA, CATB (M antigen) and CATP genes was assessed by Northern blot hybridizations on total RNA. Results at the transcript levels for these genes are shown for three conditions: cell morphology (mycelial versus yeast phase cells), oxidative stress (in response to a challenge with H(2)O(2)) and carbon source (glucose vs glycerol). Collectively, these results demonstrated regulation of CATA by both cell morphology and oxidative stress, but not by carbon source, and regulation of CATB and CATP by carbon source but not cell morphology or oxidative stress. A phylogenetic analysis of presently available catalase sequenc...Continue Reading

References

May 1, 1979·Journal of Bacteriology·B MarescaG Medoff
Jan 1, 1978·The American Journal of Medicine·S F DaviesG A Sarosi
Mar 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·E J PatriarcaB Maresca
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·K KameiD A Stevens
Mar 1, 1992·The Journal of Nutrition·G Storz, L A Tartaglia
Dec 11, 1991·Current Opinion in Genetics & Development·G F Sprague
Jan 1, 1990·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·A J HamiltonR J Hay
Jun 1, 1988·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·P L Worsham, W E Goldman
Feb 1, 1985·The American Journal of Medicine·L J WheatM L Zeckel
Mar 1, 1983·Infection and Immunity·D H Howard
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jul 1, 1981·Medicine·R A GoodwinR M Des Prez
Feb 1, 1982·Annals of Internal Medicine·L J WheatB Sathapatayavongs
Apr 1, 1994·Trends in Microbiology·B MarescaG S Kobayashi
Apr 1, 1996·Journal of Molecular Evolution·J E Mayfield, M R Duvall
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F DavidsonR H Schiestl
Sep 1, 1996·Plant Physiology·J A FrugoliC R McClung
Apr 1, 1996·Emerging Infectious Diseases·N M Ampel
Sep 1, 1997·Molecular Biology and Evolution·M G KlotzP C Loewen
Nov 14, 1997·Infection and Immunity·F J RadcliffA Lee
Nov 14, 1997·Infection and Immunity·J A CaleraJ P Latgé
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·M A De GrooteF C Fang
Mar 24, 1998·Nature·W Martin, M Müller
Feb 23, 1999·Clinical and Experimental Pharmacology & Physiology·B Demple
Mar 19, 1999·Trends in Microbiology·S L Newman
Mar 20, 1999·Infection and Immunity·R M Zancopé-OliveiraG S Deepe
May 14, 1999·Current Opinion in Microbiology·G Storz, J A Imlay
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·F C FangT Laessig

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Citations

Sep 19, 2008·Fungal Genetics and Biology : FG & B·Ronney Fernandes ChagasCélia Maria de Almeida Soares
Oct 2, 2007·Microbes and Infection·Lilian Cristiane BaezaMaria José Soares Mendes Giannini
Oct 9, 2009·Cellular Microbiology·Andreas RoetzerChristoph Schüller
Mar 12, 2005·Biochimie·Adelaida DíazWilhelm Hansberg
Jun 16, 2012·Archives of Biochemistry and Biophysics·Wilhelm HansbergLaura Domínguez
Feb 15, 2015·Biochemical and Biophysical Research Communications·Takahito ToyotomeKatsuhiko Kamei
Nov 19, 2011·FEMS Microbiology Letters·Jessica A Edwards, Chad A Rappleye
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huazhi HuangMeiying Hu
Jun 7, 2006·Annual Review of Microbiology·Chad A Rappleye, William E Goldman
Aug 5, 2014·Annual Review of Phytopathology·Darren Soanes, Thomas A Richards
Oct 18, 2008·PloS One·Allan Jefferson GuimarãesRosely Maria Zancopé-Oliveira
Jan 19, 2006·Clinical Microbiology Reviews·Nongnuch VanittanakomThira Sirisanthana
May 23, 2003·Infection and Immunity·Sophie ParisJean-Paul Latgé
Aug 13, 2003·Eukaryotic Cell·Shaday MichánWilhelm Hansberg
Mar 6, 2007·Eukaryotic Cell·Megan L Bohse, Jon P Woods
Apr 12, 2005·Eukaryotic Cell·Megan L Bohse, Jon P Woods
Mar 26, 2009·Nihon saikingaku zasshi. Japanese journal of bacteriology·Yoshiyuki Nakagawa
Sep 12, 2006·Eukaryotic Cell·Steven S GilesJohn R Perfect
Dec 1, 2020·Frontiers in Cellular and Infection Microbiology·Marcos Abreu AlmeidaRosely Maria Zancopé-Oliveira

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