Redundant and unique roles of coronin proteins in Dictyostelium.

Cellular and Molecular Life Sciences : CMLS
Maria C ShinaAngelika A Noegel

Abstract

Dictyostelium discoideum harbors a short (CRN12) and a long coronin (CRN7) composed of one and two beta-propellers, respectively. They are primarily present in the cell cortex and cells lacking CRN12 (corA⁻) or CRN7 (corB⁻) have defects in actin driven processes. We compared the characteristics of a mutant cell line (corA⁻/corB⁻) lacking CRN12 and CRN7 with the single mutants focusing on cytokinesis, phagocytosis, chemotaxis and development. Cytokinesis, uptake of small particles, and developmental defects were not enhanced in the corA⁻/corB⁻ strain as compared to the single mutants, whereas motility and phagocytosis of yeast particles were more severely impaired. It appears that although both proteins affect the same processes they do not act in a redundant manner. Rather, they often act antagonistically, which is in accordance with their proposed roles in the actin cytoskeleton where CRN12 acts in actin disassembly whereas CRN7 stabilizes actin filaments and protects them from disassembly.

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Citations

Mar 13, 2014·The Journal of Cell Biology·Evgeny ZatulovskiyRobert R Kay
Dec 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Karthic SwaminathanAngelika A Noegel
Dec 15, 2015·Cytoskeleton·Rashmi SrivastavaAmogh A Sahasrabuddhe
Sep 29, 2015·Scientific Reports·Karthic SwaminathanAngelika A Noegel
Jan 10, 2014·Molecular Biology of the Cell·Adrien F VinetJean Pieters
Jun 15, 2013·Nature Reviews. Immunology·Jean PietersRajesh Jayachandran
Mar 20, 2018·Frontiers in Cellular and Infection Microbiology·A Leoni SwartHubert Hilbi
Feb 27, 2020·International Journal of Molecular Sciences·Tohnyui Ndinyanka FabriceJean Pieters
Apr 7, 2018·Frontiers in Cellular and Infection Microbiology·Mayumi MoriJean Pieters
Nov 10, 2020·Frontiers in Cell and Developmental Biology·Chhitar M GuptaRani Bajaj

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