Reelin functions beyond neuronal migration: from synaptogenesis to network activity modulation.

Current Opinion in Neurobiology
Giulia FainiShahad Albadri

Abstract

Reelin, a glycoprotein of the extracellular matrix, has been the focus of several studies over the years, mostly for its role in cell migration. Here we report the role of this molecule and of its downstream pathways in post-mitotic neurons and how they contribute to neural circuit assembly, refinement and function. Accumulating evidence has pointed at a major role for Reelin in axonal guidance, synaptogenesis and dendritic spine formation. In particular, new evidence points at a direct role in axonal targeting and refinement at the target site. In addition, recent advances highlight new functions of Reelin in the modulation of synaptic activity, plasticity and behavior and in the direct regulation of GABA receptors expression and stability. We discuss these findings in the context of neurodevelopmental disorders.

References

Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·W S LiuE Costa
Aug 25, 2001·Annual Review of Neuroscience·D S Rice, T Curran
Nov 9, 2002·Science·Tommaso PizzorussoLamberto Maffei
Mar 20, 2003·Brain Research. Developmental Brain Research·Shunsuke SakakibaraToshio Terashima
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arancha Botella-LópezJavier Sáez-Valero
Oct 21, 2006·Nature Reviews. Neuroscience·Joachim Herz, Ying Chen
Aug 28, 2007·Molecular and Cellular Neurosciences·Victor BorrellEduardo Soriano
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanyong NiuGabriella D'Arcangelo
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jianmin SuMichael A Fox
May 24, 2013·PloS One·Emilia RomanoMaria Luisa Scattoni
Aug 21, 2013·PloS One·Inmaculada Cuchillo-IbáñezJavier Sáez-Valero
Dec 18, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Valeria BalmacedaJavier Sáez-Valero
Aug 15, 2014·Brain Structure & Function·Justyna Pielecka-FortunaSiegrid Löwel
Oct 14, 2014·The Journal of Comparative Neurology·Yuki HirotaKazunori Nakajima
Oct 7, 2015·Biochemical and Biophysical Research Communications·Sung-Kuk ChoYoung-Don Lee
Jun 1, 2016·Frontiers in Cellular Neuroscience·Gum Hwa Lee, Gabriella D'Arcangelo
Jun 17, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yulan JiangMinh Dang Nguyen
Jul 26, 2016·Frontiers in Cellular Neuroscience·Hans H Bock, Petra May
Aug 18, 2016·Scientific Reports·Inmaculada Cuchillo-IbañezJavier Sáez-Valero
Oct 26, 2016·Journal of Cellular Physiology·Estibaliz AmpueroBrigitte van Zundert
Nov 3, 2016·Frontiers in Cellular Neuroscience·Kazuhiro IshiiKazunori Nakajima
Dec 21, 2016·The Journal of Biological Chemistry·Catherine R Wasser, Joachim Herz
Feb 12, 2017·Nature Communications·Devon C CrawfordEge T Kavalali
May 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Burkhard JakobVolker Haucke
Jun 8, 2017·Frontiers in Cellular Neuroscience·Michael FrotscherXuejun Chai
Feb 15, 2018·The EMBO Journal·Jung-Hyun ChoiKyung-Tai Min
Feb 15, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Trinidad Mata-BalaguerJavier Sáez-Valero
Apr 26, 2019·The International Journal of Biochemistry & Cell Biology·Nicholas C ArmstrongKieran W McDermott
Sep 19, 2019·Neural Plasticity·Shilian XuXiaomin Zhang
Oct 15, 2019·Frontiers in Behavioral Neuroscience·Elisa Dalla VecchiaWilliam H J Norton

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