Reelin immunoreactivity in the adult neocortex: a comparative study in rodents, carnivores, and non-human primates

Brain Research Bulletin
Verónica Martínez-Cerdeño, Francisco Clascá

Abstract

Recent evidence indicates that, in addition to playing a crucial role in early cortical development, intercellular signaling mediated by the protein Reelin may be widely active in the adult neocortex. The extent of Reelin distribution and its functional role in the adult are not clear yet. Here, we have examined Reelin immunoreactivity in the neocortex of an adult rodent (rat, Rattus norvegicus), a carnivore (ferret, Mustela putorius), and a primate (macaque monkeys Macaca nemestrina, Macaca mulatta) at the optic microscope level. Our data show that the neocortex of all three species contains several morphologically distinct populations of interneurons whose perikaryon and proximal dendritic processes are heavily immunoreactive for Reelin. The laminar distribution of these cells is species-specific. In addition, discrete reelin-immunoreactive pericellular structures are present in virtually all neocortical neurons of macaques.

References

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Citations

Mar 26, 2016·Frontiers in Cellular Neuroscience·Hector CarcellerRamon Guirado
Jan 24, 2020·Frontiers in Neuroanatomy·Agnieszka KrzyzanowskaTania Ramos-Moreno
Apr 25, 2003·Cell and Tissue Research·Philippe AbsilMarcel Eens
Jun 18, 2003·The Journal of Comparative Neurology·Verónica Martínez-CerdeñoFrancisco Clascá
Jan 20, 2006·The European Journal of Neuroscience·Tania Ramos-MorenoFrancisco Clascá
Aug 19, 2007·Journal of Neurochemistry·Nobutaka OhkuboNoriaki Mitsuda
Jul 6, 2014·Frontiers in Neuroanatomy·Verónica Martínez-Cerdeño, Stephen C Noctor
Jan 27, 2017·Cerebral Cortex·Jeanelle ArizaVerónica Martínez-Cerdeño
Feb 4, 2005·The Journal of Comparative Neurology·Rosalinda C RobertsBrian Kirkpatrick

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