Reelin is a platelet protein and functions as a positive regulator of platelet spreading on fibrinogen.

Cellular and Molecular Life Sciences : CMLS
Wei-Lien TsengChing-Ping Tseng

Abstract

Abnormalities of platelet functions have been linked to reelin-impaired neuronal disorders. However, little attention has been given to understanding the interplay between reelin and platelet. In this study, reelin was found to present in the human platelets and megakaryocyte-like leukemic cells. Reelin-binding assays revealed that extracellular reelin can interact with platelets through the receptor belonging to the low density lipoprotein receptor gene family. The reelin-to-platelet interactions enhance platelet spreading on fibrinogen concomitant with the augmentation of lamellipodia formation and F-actin bundling. In contrast, reelin has no effect on integrin alphaIIbbeta3 activation and agonist-induced platelet aggregation. Molecular analysis revealed that the up-regulation of Rac1 activity and the inhibition of protein kinase C delta-Thr505 phosphorylation are important for reelin-mediated enhancement of platelet spreading on fibrinogen. These findings demonstrate for the first time that reelin is present in platelets and the reelin-to-platelet interactions play a novel role in platelet signaling and functions.

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Citations

Mar 5, 2016·Frontiers in Cellular Neuroscience·Hector J CarunchoLisa E Kalynchuk
Sep 27, 2014·Journal of Thrombosis and Haemostasis : JTH·W-L TsengC-P Tseng
Apr 19, 2015·BMC Neuroscience·Emma Perez-CostasHector J Caruncho
Oct 16, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elvira Khialeeva, Ellen M Carpenter
Sep 7, 2017·Journal of Thrombosis and Haemostasis : JTH·H-J TsaiC-P Tseng
Aug 14, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Irena KruegerMargitta Elvers
Sep 24, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Sarah M Hicks, Elizabeth E Gardiner
Mar 9, 2019·Journal of Hematology & Oncology·Jiansong HuangJie Jin
Nov 26, 2020·International Journal of Molecular Sciences·Benedetta IzziAlessandro Gialluisi
Oct 30, 2020·International Journal of Molecular Sciences·Madhumita ChatterjeeMargitta Elvers

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