Abstract
Enterovirus 71 (EV71) belongs to picornavirus family and could be classified phylogenetically into three major genogroups (A, B and C) including 11 genotypes (A, B1-B5 and C1-C5). Since 1997, EV71 has caused large-scale of epidemics with neurological complications in Asian children. In Taiwan, nationwide EV71 epidemics with different predominant genotypes have occurred cyclically since 1998. A nationwide EV71 epidemic occurred again in 2012. We conducted genetic and antigenic characterizations of the 2012 epidemic. Chang Gung Memorial Hospital (CGMH) is a medical center in northern Taiwan. In CGMH, specimens were collected from pediatric inpatients with suspected enterovirus infections for virus isolation. Enterovirus isolates were serotyped and genotyped and sera from EV71 inpatients were collected for measuring neutralizing antibody titers. There were 10, 16 and 99 EV71 inpatients identified in 2010, 2011 and 2012, respectively. There were 82 EV71 isolates genotyped, which identified 17 genotype C4a viruses and 65 genotype B5 viruses. The genotype B5 viruses were not detected until November 2011 and caused epidemics in 2012. Interestingly, the B5-2011 viruses were genetically distinguishable from the B5 viruses causing the 20...Continue Reading
References
Sep 25, 1999·The New England Journal of Medicine·M HoS R Shih
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Luan-Yin ChangTzou-Yien Lin
Nov 23, 2006·Pediatrics·Mei-Chih HuangChing-Chuan Liu
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mong How OoiTom Solomon
Mar 23, 2007·The New England Journal of Medicine·Luan-Yin ChangTzou-Yien Lin
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 23, 2007·Journal of Clinical Microbiology·Tsuey-Li LinChen-Fu Yang
Sep 25, 2009·Journal of Clinical Microbiology·Sheng-Wen HuangJen-Ren Wang
Dec 29, 2009·Journal of Virological Methods·Mei-Liang HuangMin-Shi Lee
Mar 23, 2010·Virus Genes·Haiyang YuMingli Wang
Oct 21, 2010·Virology Journal·Yuan-Pin HuangHo-Sheng Wu
Feb 22, 2012·PLoS Neglected Tropical Diseases·Min-Shi LeeTzou-Yien Lin
Jul 25, 2012·Lancet·Abby Seiff
Sep 7, 2012·PLoS Neglected Tropical Diseases·Min-Shi LeeIh-Jen Su
Oct 20, 2012·Virus Genes·Xingliang FanBianli Xu
Oct 25, 2012·Emerging Infectious Diseases·C Durga RaoK Subbanna Shankarappa
Dec 1, 2012·Emerging Infectious Diseases·Truong Huu KhanhH Rogier van Doorn
Feb 19, 2013·PloS One·Junping ZhuJing An
Mar 6, 2013·PLoS Neglected Tropical Diseases·Mei-Liang HuangMin-Shi Lee
Aug 8, 2013·PloS One·Le Phan Kim ThoaMin-Shi Lee
Oct 15, 2013·Pediatrics and Neonatology·Min-Yuan ChiaMin-Shi Lee
Dec 19, 2013·PloS One·Yuan-Pin HuangHo-Sheng Wu
Dec 29, 2013·Genome Announcements·Zhu YangFenyong Liu
Jan 7, 2014·PloS One·Wen-Hao WuYi-Ming Arthur Chen
Citations
Mar 20, 2016·Journal of Ethnopharmacology·Ya Ju HsiehJung San Chang
Sep 22, 2016·Emerging Microbes & Infections·Veasna DuongPhilippe Buchy
Dec 3, 2016·The Journal of General Virology·Mei-Feng Chen, Shin-Ru Shih
Oct 14, 2017·The Journal of Infectious Diseases·Nguyen Thi Thanh ThaoDhanasekaran Vijaykrishna
Oct 17, 2017·European Journal of Clinical Investigation·Jun-Jun YehWu-Huei Hsu
Jan 10, 2018·The Pediatric Infectious Disease Journal·Vincent Chin-Hung ChenChung-Yao Hsu
Aug 9, 2016·Medicine·Yu-Nong GongKuo-Chien Tsao
Dec 1, 2019·Microbiology and Immunology·Zhihui LiYueran Zhao
Oct 20, 2019·Journal of Biomedical Science·Jiratchaya PuenpaYong Poovorawan
Dec 3, 2016·PloS One·Wan-Yu ChungMin-Shi Lee
Nov 13, 2019·Journal of Biomedical Science·An-Ting LiouChiaho Shih
Jun 6, 2021·Scientific Reports·You-Lin TainChien-Ning Hsu