Reemergence of enterovirus 71 epidemic in northern Taiwan, 2012

PloS One
Shu-Ting LuoMin-Shi Lee

Abstract

Enterovirus 71 (EV71) belongs to picornavirus family and could be classified phylogenetically into three major genogroups (A, B and C) including 11 genotypes (A, B1-B5 and C1-C5). Since 1997, EV71 has caused large-scale of epidemics with neurological complications in Asian children. In Taiwan, nationwide EV71 epidemics with different predominant genotypes have occurred cyclically since 1998. A nationwide EV71 epidemic occurred again in 2012. We conducted genetic and antigenic characterizations of the 2012 epidemic. Chang Gung Memorial Hospital (CGMH) is a medical center in northern Taiwan. In CGMH, specimens were collected from pediatric inpatients with suspected enterovirus infections for virus isolation. Enterovirus isolates were serotyped and genotyped and sera from EV71 inpatients were collected for measuring neutralizing antibody titers. There were 10, 16 and 99 EV71 inpatients identified in 2010, 2011 and 2012, respectively. There were 82 EV71 isolates genotyped, which identified 17 genotype C4a viruses and 65 genotype B5 viruses. The genotype B5 viruses were not detected until November 2011 and caused epidemics in 2012. Interestingly, the B5-2011 viruses were genetically distinguishable from the B5 viruses causing the 20...Continue Reading

References

Sep 25, 1999·The New England Journal of Medicine·M HoS R Shih
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Luan-Yin ChangTzou-Yien Lin
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mong How OoiTom Solomon
Mar 23, 2007·The New England Journal of Medicine·Luan-Yin ChangTzou-Yien Lin
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Sep 25, 2009·Journal of Clinical Microbiology·Sheng-Wen HuangJen-Ren Wang
Dec 29, 2009·Journal of Virological Methods·Mei-Liang HuangMin-Shi Lee
Oct 21, 2010·Virology Journal·Yuan-Pin HuangHo-Sheng Wu
Jul 25, 2012·Lancet·Abby Seiff
Sep 7, 2012·PLoS Neglected Tropical Diseases·Min-Shi LeeIh-Jen Su
Oct 25, 2012·Emerging Infectious Diseases·C Durga RaoK Subbanna Shankarappa
Dec 1, 2012·Emerging Infectious Diseases·Truong Huu KhanhH Rogier van Doorn
Oct 15, 2013·Pediatrics and Neonatology·Min-Yuan ChiaMin-Shi Lee

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Citations

Oct 14, 2017·The Journal of Infectious Diseases·Nguyen Thi Thanh ThaoDhanasekaran Vijaykrishna
Oct 17, 2017·European Journal of Clinical Investigation·Jun-Jun YehWu-Huei Hsu
Oct 20, 2019·Journal of Biomedical Science·Jiratchaya PuenpaYong Poovorawan

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