Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes

Archivum Immunologiae Et Therapiae Experimentalis
Y Maurice MorillonRoland Tisch

Abstract

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells are selectively destroyed. β cell-specific T cells are considered to be the major mediators of pathology. Accordingly, most immunotherapies tested in the clinic to date have focused on reestablishing self-tolerance within the T cell compartment. Monoclonal antibodies (Ab) targeting a variety of lymphocyte surface proteins have demonstrated benefits in preclinical and clinical settings. Indeed, the use of Ab to target T cells directly or indirectly has proven to be an effective strategy to rapidly suppress β cell autoimmunity and establish tissue-specific, long-term tolerance in rodent T1D models. In this review, we describe a number of these Ab-based immunotherapies, discuss associated immune regulatory mechanisms, and highlight results obtained in T1D clinical trials.

References

Jul 15, 1989·Lancet·L ChatenoudJ F Bach
Aug 1, 1994·Endocrine Reviews·J F Bach
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Bach
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·L WeissD Naor
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J M GreenA S Shaw
Aug 10, 2000·Diabetes/metabolism Research and Reviews·H E Thomas, T W Kay
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A HolzM B Oldstone
Jul 28, 2001·The New England Journal of Medicine·C N EllisUNKNOWN Alefacept Clinical Study Group
Oct 6, 2001·The New England Journal of Medicine·S MartinB O Roep
May 31, 2002·The New England Journal of Medicine·Kevan C HeroldJeffrey A Bluestone
Feb 6, 2003·The Journal of Clinical Investigation·Kevan C HeroldJeffrey A Bluestone
Feb 15, 2003·International Immunopharmacology·Paolo MontiLorenzo Piemonti
Mar 5, 2003·European Journal of Immunology·Joanne C CooperDenis R Alexander
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qizhi TangJeffrey A Bluestone
Feb 3, 2004·The Journal of Clinical Investigation·Sefina ArifMark Peakman
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo A SilveiraDavid V Serreze
Mar 18, 2005·Annual Review of Immunology·Mark S Anderson, Jeffrey A Bluestone
Jun 24, 2005·The New England Journal of Medicine·Bart KeymeulenLucienne Chatenoud
Sep 17, 2005·The Journal of Clinical Investigation·Brygida BisikirskaKevan C Herold
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jide TianDaniel L Kaufman
Apr 22, 2006·The Journal of Clinical Investigation·Damien BressonMatthias von Herrath
Aug 16, 2006·The New England Journal of Medicine·Ganesh SuntharalingamNicki Panoskaltsis
Nov 23, 2006·The Journal of Experimental Medicine·Brian T FifeJeffrey A Bluestone
Nov 30, 2006·Annals of the New York Academy of Sciences·Mohamed M Jahromi, George S Eisenbarth
Mar 1, 2007·Diabetes·Roberto MallonePeter van Endert
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sylvaine YouLucienne Chatenoud
Dec 7, 2007·The Journal of Clinical Investigation·Chang-yun HuLi Wen
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan XiuThomas F Tedder

❮ Previous
Next ❯

Citations

Oct 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y Maurice MorillonRoland Tisch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2021 Meta ULC. All rights reserved