Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology.

Cancer Biology & Therapy
Daniel E AbbottMary J C Hendrix

Abstract

Cathepsin D is a lysosomal hydrolase involved in intra- and extracellular proteolysis. This enzyme is aberrantly produced and processed in malignancy, and most notably is over-secreted into the tumor cell microenvironment. This hyper-secretion may lead to excessive degradation of the extracellular matrix, and contribute to tumor progression and metastases. These phenomena have been established in vitro, and there is evidence that Cathepsin D is similarly dysregulated in human breast cancer patients. Because breast cancer lacks an effective screening or surveillance biomarker, here we address the hypothesis that serum Cathepsin D activity may be useful to assess the presence or progression of breast cancer in females. While representative histologic sections from various disease-specific cohorts confirm previous findings that increased Cathepsin D production and secretion correlate with tumor progression, we report no difference in serum Cathepsin D activity between patients who are disease free, patients with pre-invasive or limited invasive disease, and patients with metastatic disease. Furthermore, in patients with known metastatic disease, there were no clinical variables associated with significantly different serum Catheps...Continue Reading

Citations

Apr 6, 2012·Archives of Gynecology and Obstetrics·Yun ChaiJianhong Zhou
Mar 28, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasuhiro Tsume, Gordon L Amidon
Jun 11, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Galina S ZamayAnna S Zamay
May 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tijl VermassenSylvie Rottey
Nov 11, 2010·British Journal of Cancer·T LampejoS Cleator
Apr 24, 2021·IScience·Shyong Quan YapRobert Joseph Huber
Jun 10, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema PatelNadeem Akhtar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.