Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model

Journal of Neurodegenerative Diseases
Jordan T NewingtonRobert C Cumming

Abstract

The conventional view of central nervous system (CNS) metabolism is based on the assumption that glucose is the main fuel source for active neurons and is processed in an oxidative manner. However, since the early 1990s research has challenged the idea that the energy needs of nerve cells are met exclusively by glucose and oxidative metabolism. This alternative view of glucose utilization contends that astrocytes metabolize glucose to lactate, which is then released and taken up by nearby neurons and used as a fuel source, commonly known as the astrocyte-neuron lactate shuttle (ANLS) model. Once thought of as a waste metabolite, lactate has emerged as a central player in the maintenance of neuronal function and long-term memory. Decreased neuronal metabolism has traditionally been viewed as a hallmark feature of Alzheimer's disease (AD). However, a more complex picture of CNS metabolism is emerging that may provide valuable insight into the pathophysiological changes that occur during AD and other neurodegenerative diseases. This review will examine the ANLS model and present recent evidence highlighting the critical role that lactate plays in neuronal survival and memory. Moreover, the role of glucose and lactate metabolism in...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 1, 1991·Annals of the New York Academy of Sciences·W D HeissK Herholz
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J PrichardR Shulman
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T Fox, M E Raichle
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Jan 17, 1996·Annals of the New York Academy of Sciences·P J Magistretti, L Pellerin
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P G BittarP J Magistretti
Apr 1, 1997·Trends in Neurosciences·J Hardy
Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Sep 25, 1997·Journal of Neuroscience Research·R L LeinoL R Drewes
Apr 8, 1998·Annual Review of Neuroscience·A J SilvaS Kida
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W J PowersT O Videen
Oct 21, 1998·Developmental Neuroscience·L PellerinP J Magistretti
Dec 30, 1998·Journal of Neural Transmission·R MielkeW D Heiss
Dec 30, 1998·Journal of Neural Transmission·G E GibsonJ P Blass
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·G A BrooksC E Butz
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Aug 12, 1999·Journal of Neural Transmission·M BiglK Eschrich
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B Hassel, A Bråthe
Dec 9, 2000·Developmental Neuroscience·H QuU Sonnewald
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Dec 18, 2001·Journal of Neuroscience Research·G A Dienel, L Hertz
Jan 18, 2002·Journal of Neurochemistry·C S CasleyM A Sharpe
Jun 4, 2002·The Journal of Physiology·Kent SahlinMichail Tonkonogi
Apr 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoshiaki ItohLouis Sokoloff
Jun 11, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Diarmuid SmithStephanie A Amiel
Oct 3, 2003·Trends in Neurosciences·Maiken NedergaardSteven A Goldman
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ching-Ping Chih, Eugene L Roberts

❮ Previous
Next ❯

Citations

Jan 24, 2014·Journal of Neuroscience Research·Joseph LemireVasu D Appanna
Dec 18, 2019·PloS One·Dimitris G PatsatzisS Mani Sarathy
Oct 30, 2014·Apoptosis : an International Journal on Programmed Cell Death·A BobbaA Atlante
Jan 18, 2020·International Journal of Molecular Sciences·Motaz M FadulJulie E Simpson
Feb 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hsiao-Chien TingHorng-Jyh Harn
Nov 2, 2018·Journal of Neuropathology and Experimental Neurology·Mao ZhangZhongxiang Yao
Nov 28, 2019·The Biochemical Journal·Marta Sidoryk-Węgrzynowicz, Lidia Strużyńska
Nov 12, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena Labieniec-WatalaCezary Watala
Dec 17, 2014·Frontiers in Neuroscience·Daniel A Kane
Feb 18, 2017·Frontiers in Neuroscience·Shayne Mason
Feb 13, 2021·Journal of Personalized Medicine·Luigi DonatoRosalia D'Angelo

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
antisense oligodeoxynucleotides
transgenic

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Ching-Ping Chih, Eugene L Roberts
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Agnès Aubert, Robert Costalat
Neurochemistry International
Marianne Fillenz
© 2021 Meta ULC. All rights reserved