Reevaluating the imaging definition of tumor progression: perfusion MRI quantifies recurrent glioblastoma tumor fraction, pseudoprogression, and radiation necrosis to predict survival.

Neuro-oncology
Leland S HuLeslie C Baxter

Abstract

Contrast-enhanced MRI (CE-MRI) represents the current mainstay for monitoring treatment response in glioblastoma multiforme (GBM), based on the premise that enlarging lesions reflect increasing tumor burden, treatment failure, and poor prognosis. Unfortunately, irradiating such tumors can induce changes in CE-MRI that mimic tumor recurrence, so called post treatment radiation effect (PTRE), and in fact, both PTRE and tumor re-growth can occur together. Because PTRE represents treatment success, the relative histologic fraction of tumor growth versus PTRE affects survival. Studies suggest that Perfusion MRI (pMRI)-based measures of relative cerebral blood volume (rCBV) can noninvasively estimate histologic tumor fraction to predict clinical outcome. There are several proposed pMRI-based analytic methods, although none have been correlated with overall survival (OS). This study compares how well histologic tumor fraction and OS correlate with several pMRI-based metrics. We recruited previously treated patients with GBM undergoing surgical re-resection for suspected tumor recurrence and calculated preoperative pMRI-based metrics within CE-MRI enhancing lesions: rCBV mean, mode, maximum, width, and a new thresholding metric called ...Continue Reading

References

Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R MacdonaldJ G Cairncross
Mar 1, 1995·Journal of Neurosurgery·P A ForsythE J Atkinson
Jan 28, 2003·Journal of Neurosurgery·Christian B BärlocherRolf W Seiler
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Feb 8, 2006·Acta Neuropathologica·Arie Perry, Robert E Schmidt
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
May 3, 2008·The Lancet Oncology·Dieta BrandsmaMartin J van den Bent
Apr 8, 2009·Current Neurology and Neuroscience Reports·Jennifer L Clarke, Susan Chang
Sep 23, 2009·Current Opinion in Neurology·Dieta Brandsma, Martin J van den Bent
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Apr 30, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Craig J GalbánBrian D Ross
Mar 24, 2012·The American Journal of Surgical Pathology·Jang-Hee KimKyi Beom Lee

❮ Previous
Next ❯

Citations

Nov 28, 2012·Nature Reviews. Clinical Oncology·Shota TanakaJorg Dietrich
Jul 17, 2013·Neuro-oncology·Brian M AlexanderDonald A Berry
Apr 18, 2014·Journal of Neurosciences in Rural Practice·Vivek TiwariKamal Verma
Dec 3, 2014·Neuro-oncology·Leor ZachYael Mardor
Dec 6, 2014·Neuroimaging Clinics of North America·L Celso Hygino da Cruz, Margareth Kimura
Dec 3, 2013·Critical Reviews in Oncology/hematology·Paolo G Gobbi
Apr 25, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Stella BlaselElke Hattingen
May 7, 2013·Magnetic Resonance Imaging Clinics of North America·Mark S ShiroishiMeng Law
Jan 5, 2016·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Roh-Eul Yoo, Seung Hong Choi
Mar 6, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Muhammad M Abd-El-BarrJohn H Chi
Sep 12, 2015·AJNR. American Journal of Neuroradiology·L S HuB J Erickson
Oct 15, 2013·NMR in Biomedicine·J W M BeenakkerA G Webb
Mar 23, 2015·European Journal of Radiology·Timothy Pok Chi YeungTing-Yim Lee
Jun 13, 2015·AJNR. American Journal of Neuroradiology·M A PrahK M Schmainda
Sep 14, 2015·Neuro-oncology·Mark S ShiroishiWhitney B Pope
Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Chun-Pu ZhangWen-Jing Pan
Jul 15, 2015·Nuclear Medicine and Biology·Christopher BellStephen Rose
Sep 29, 2015·BioMed Research International·Adrian Ion-MargineanuSabine Van Huffel
Apr 25, 2015·AJNR. American Journal of Neuroradiology·K WelkerUNKNOWN American Society of Functional Neuroradiology MR Perfusion Standards and Practice Subcommittee of the ASFNR Clinical Practic
Apr 22, 2015·Journal of Neuro-oncology·Isaac Melguizo-GavilanesVinay K Puduvalli
Mar 10, 2015·Current Treatment Options in Neurology·Martha R NeaguPatrick Y Wen
Mar 10, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CiconeKarl-Josef Langen
Oct 28, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Yang YuJinyuan Zhou
Aug 10, 2016·Neuro-oncology·Leland S HuJ Ross Mitchell
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Jerrold L BoxermanWhitney B Pope
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Raymond Y Huang, Patrick Y Wen

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical
biopsy
surgical resection
biopsies
surgical re-resection

Software Mentioned

ITK
Insight Segmentation and Registration Toolkit
pMRI
PTRE
Imaging Biometrics

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.