PMID: 8607614Dec 1, 1995Paper

Reevaluation of preneoplastic lung lesions in lung carcinoma? In bronchial carcinoma?

Gan to kagaku ryoho. Cancer & chemotherapy
H KatoC Konaka

Abstract

Since the genetic model for colorectal carcinogenesis was presented by Fearon and Vogelstein, carcinogenesis has been thought to occur based on the accumulation of gene-mutations. In this context, preneoplastic lesions may be morphological phenotypes of different steps during multistep carcinogenesis. Historically, autopsy findings reported by Auerbach and cytological findings by Nasiell and Saccomanno support the idea that bronchial squamous metaplasia (BSM) with atypia is a preneoplastic lesion in large bronchi. Thereafter, the de novo theory became prevalent, because BSM was almost never shown to appear immediately adjacent to tiny bronchial neoplasias on examinations of resected lung materials. However, advanced molecular biological analysis shows that BSM with various grades of atypia has been found to correlate with cellular and genetic alterations (e.g., hyperproliferation, genomic instability, deletion of 3p and p53 tumor-suppressor gene etc.). These findings suggested that BSM with atypia might be a preneoplastic lesion of bronchial squamous cell carcinoma. Recently, it was shown that similar kinds of sequential genetic changes occurred in atypical adenomatous hyperplasia (AAH). It was also suggested that AAH might be ...Continue Reading

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.