PMID: 9177230Jun 10, 1997Paper

Reexamination of human T cell lymphotropic virus (HTLV-I/II) prevalence

Proceedings of the National Academy of Sciences of the United States of America
D Zucker-FranklinP M Legler

Abstract

In the United States, blood donors are being screened for infection with human T cell lymphotropic viruses I and II (HTLV-I/II) by serologic means, which detect antibodies to the structural proteins of these viruses. Because patients with mycosis fungoides (MF) usually do not have such antibodies even though their cells harbor HTLV-I Tax and/or pol proviral sequences, it was questioned whether the prevalence of HTLV infection among healthy blood donors may also be underestimated by current means of testing. To examine this possibility, a study on specimens of relatives of mycosis fungoides patients (MFR) was begun. In addition, to collect data more expeditiously, a cohort of former injection drug users (IDUs) was tested by routine serologic methods, as well as by PCR/Southern blot analysis for Tax, pol, and gag proviral sequences and Western blot analysis for antibodies to the Tax gene product. To date, 6/8 MFRs and 42/81 (51.8%) of HIV-negative IDUs proved to be positive for HTLV, whereas routine serology identified none of the MFR and only 18/81 (22.2%) of the IDUs. Among the latter test subjects, the incidence of HTLV-I also proved to be 10 times higher than expected. Therefore, it is likely that among healthy blood donors i...Continue Reading

References

Oct 1, 1992·The Journal of Infectious Diseases·P E PalumboR Altman
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D Zucker-FranklinD C Zouzias
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K ShimotohnoT Sugimura
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
May 1, 1995·Journal of the American Dietetic Association·A M HutchinsJ W Lampe
Mar 1, 1995·The Journal of Clinical Investigation·V Bennett
Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·S ShioiriN Mueller
Dec 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·B A Pancake, D Zucker-Franklin

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Citations

Nov 15, 2002·Journal of Biomedical Science·Anna Bárbara F Carneiro-ProiettiUNKNOWN GIPH (Interdisciplinary HTLV-1/II Research Group)
Aug 7, 2002·Current Oncology Reports·Wing Y Au, Raymond Liang
Jul 10, 2003·Blood Cells, Molecules & Diseases·Dorothea Zucker-FranklinVesna Najfeld
Sep 30, 1999·Transfusion·W H Dzik, A Okayama
Jul 31, 2002·Transfusion·Rigmor ThorstenssonSören Andersson
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A VetF R Kramer
Dec 21, 2000·Current Rheumatology Reports·D Zucker-Franklin
Mar 20, 2019·International Journal of Dermatology·Brena Andrade de SousaMarília B Xavier
Mar 7, 2000·Clinical and Diagnostic Laboratory Immunology·D Zucker-FranklinM Khorshidi
Feb 12, 2020·The American Journal of Tropical Medicine and Hygiene·Sandra GallegoSilvia Nates
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Charlene S DezzuttiElliot P Cowan
Oct 12, 2001·Annals of the New York Academy of Sciences·D Zucker-Franklin
Nov 5, 1998·Clinical and Diagnostic Laboratory Immunology·D Zucker-Franklin, B A Pancake

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