Reexcision perineural invasion: a mimic of malignancy

The American Journal of Dermatopathology
Trevor W Beer

Abstract

The presence of epithelium in the perineural space is typically associated with invasion by malignant tumors. In this report, bland-appearing epithelium was identified in the perineural space associated with a dermal reparative reaction after removal of a melanoma in 4 patients. After exclusion of possible squamous cell carcinoma and immunohistochemistry, a diagnosis of reexcision perineural invasion was made. The report illustrates the features of this uncommon and little recognized entity which has not been previously reported in the dermatology or dermatopathology literature. A lack of appreciation of the condition may lead to a misdiagnosis of malignancy, especially squamous cell carcinoma. The cases also highlight the need for good clinical correlation when examining reexcision specimens. There may be increased recognition of reexcision perineural invasion with the rise in reexcisions that are being performed, with some surgeons reexcising Spitz nevi and dysplastic nevi, for example.

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Citations

Apr 7, 2007·The American Journal of Dermatopathology·Jere B Stem, Helen M Haupt
Apr 7, 2007·The American Journal of Dermatopathology·Stewart F Cramer
Jan 22, 2009·The American Journal of Dermatopathology·Trevor W Beer
Jun 8, 2010·The American Journal of Dermatopathology·Arash RonaghyJag Bhawan
Feb 14, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Martin DunnTrevor W Beer
Feb 13, 2009·Journal of Cutaneous Pathology·Martin DunnScott M Acker
Jul 27, 2012·Journal of Cutaneous Pathology·Trevor W Beer, Paul Drury
Sep 16, 2010·Journal of Cutaneous Pathology·Trevor W Beer
Feb 18, 2012·Journal of Cutaneous Pathology·Timothy H McCalmont
Feb 18, 2012·Journal of Cutaneous Pathology·Jaroslaw JedrychJennifer M McNiff
Jul 21, 2009·Journal of Cutaneous Pathology·Charles J Bechert, Jere B Stern
Apr 25, 2008·Advances in Anatomic Pathology·Sergio Piña-Oviedo, Carlos Ortiz-Hidalgo
Feb 10, 2017·Advances in Anatomic Pathology·Mansour MoghimiAmir Aryanfar

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