Aug 1, 1994

Reference data for bone mass, calciotropic hormones, and biochemical markers of bone remodeling in older (55-75) postmenopausal white and black women

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M KleerekoperP Wilson

Abstract

From a random sample of our institution's health maintenance organization (HMO), we recruited 250 white women and 112 black women, aged 55-75, all of whom were 10 or more years postmenospause with minimal estrogen exposure and free of osteoporosis, other metabolic bone disease, and medical, surgical, or therapeutic situations that may influence bone loss. Bone mass was measured in the radius, spine, and femur by DXA and in L1 by QCT. Serum samples were analyzed for parathyroid hormone, calcidiol, calcitriol, osteocalcin, and bone alkaline phosphatase and urine samples analyzed for creatinine, calcium, and hydroxyproline. Mean Z score, based on published reference data for forearm and femoral neck BMD in the white women, was not significantly different from zero, but mean Z score at the lumbar spine was 0.6 (p < 0.001), 17.2% of the individual values being > 2.0. In normal white women (BMI < 27.3, n = 143), Z score was still > 2.0 in 10.3%, suggesting that the upper bound of the published reference interval may be too low. After adjustment for body mass index, BMD was greater in the forearm (9.8%), spine (8.7%), and femoral neck (14.7%) in black women (p < 0.001 at all sites). At L1, adjusted BMC in the black women was 37.4% gre...Continue Reading

  • References30
  • Citations44

References

  • References30
  • Citations44

Citations

Mentioned in this Paper

Parathyroid Hormone Peptide (1-34)
African Continental Ancestry Group
Bone Mineral Content
Alveolar Bone Loss
European Continental Ancestry Group
Postmenopause
Metabolic Bone Disorder
Osteoporosis
Bone Remodeling
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