Reference interval for immature platelet fraction on Sysmex XN haematology analyser in adult population

Biochemia Medica
Claudia E ImperialiDolors Dot-Bach

Abstract

The Sysmex XN-series haematology analyser has newly adopted a fluorescent channel to measure immature platelet fraction (IPF). To promote the clinical utility of this promising parameter, establishing a reliable reference interval is mandatory. According to previous studies, IPF values may be affected by the employed analyser and the ethnic background of the individual, but no differences seem to be found between individuals' genders. Therefore, this study aimed to define the reference interval for IPF in a Spanish population following Clinical and Laboratory Standard Institute (CLSI) guidelines. A total of 153 healthy Caucasian adults from Spain met the inclusion criteria. IPF measurement was performed by means of a Sysmex XN-2000 haematology analyser. A non-parametric percentile method was used to calculate the reference intervals in accordance with CLSI guidelines. The obtained reference interval for IPF on the Sysmex XN-2000 was 1.6-9.6% (90% confidence intervals (CIs) were 1.5-1.8 and 9.3-11.5, respectively). No significant gender difference in IPF reference intervals was observed (P = 0.101). This study provides, for the first time, a reference interval for IPF using a Sysmex XN-2000 in a Spanish population, ranging from ...Continue Reading

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Citations

Mar 20, 2020·Journal of Clinical Medicine·Véronique BacciniValérie Bardet
Nov 17, 2019·Journal of Clinical Pathology·Claudia Elizabeth ImperialiLourdes Sanchez-Navarro
May 20, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rasha A El-GamalMary Z Fayek
May 3, 2020·Pediatrics in Review·Kristina M Haley
Jul 22, 2021·Journal of Clinical Laboratory Analysis·Fangfang YangYonglie Zhou
Aug 15, 2021·Journal of Thrombosis and Haemostasis : JTH·Harriet E AllanTimothy D Warner

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

STATA®

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