Reference intervals for reticulocyte hemoglobin content in healthy infants

Pediatric Research
Anders LöfvingOla Andersson

Abstract

Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48-72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He. Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1-37.7 pg/L (N = 253) at 48-72 h, 25.6-33.4 pg/L (N = 341) at four months and 24.9-34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) -4.2 pg/L (-6.1 to -2.4) and at 12 months mean difference (95% CI) -3.4 pg/L (-5.0 to -1.8). This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.

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Citations

Feb 12, 2020·Journal of Clinical Laboratory Analysis·Pawadee ChinudomwongKaran Paisooksantivatana
May 31, 2020·Nutrients·Genny RaffaeliStefano Ghirardello
Oct 31, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kanhai AminSanjiv Amin
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Aug 28, 2019·Nutrients·Luis Pereira-da-SilvaChristoph Fusch
Oct 6, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Timothy M BahrRobert D Christensen
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May 15, 2021·Blood Cells, Molecules & Diseases·Timothy M BahrRobert D Christensen
Dec 4, 2021·International Journal of Laboratory Hematology·Fernando Javier Bracho

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Methods Mentioned

BETA
cesarean section

Software Mentioned

SPSS Statistics

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