Reference intervals for serum lipids and prevalence of dyslipidaemia in 6-12-year-old children: The Health Oriented Pedagogical Project (HOPP)

Scandinavian Journal of Public Health
Martin Frank StrandMorten Lindberg

Abstract

Elevated serum lipid concentrations in childhood are thought to be risk factors for the development of cardiovascular disease later in life. The present study aims to provide age- and gender-related reference intervals for total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol in healthy school children. We also investigated the prevalence of dyslipidaemia using the published criteria for these biomarkers. Venous blood and anthropometric data were collected from 1340 children in the HOPP study, aged between 6 and 12 years. Age- and gender-related reference intervals (2.5th and 97.5th percentiles) were established according to the IFCC recommendations, using the software RefVal 4.10. Gender differences were observed for total cholesterol and non-HDL cholesterol, but not for HDL cholesterol. Age differences were observed for total cholesterol. The reference intervals were in the range of 3.1-5.9 mmol/L for total cholesterol, 1.0-2.4 mmol/L for HDL cholesterol and 1.4-4.2 mmol/L for non-HDL cholesterol. Dyslipidaemia prevalence was as follows: increased TC 9.6%, decreased HDL 1.6%, and increased non-HDL 5.6%. Age- and gender-related reference intervals in a Norwegian population are similar to t...Continue Reading

References

Aug 26, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Helge Erik Solberg
May 22, 2010·Current Opinion in Pediatrics·Holly C Gooding, Sarah D de Ferranti
Mar 2, 2012·Clinical Chemistry·Ferruccio Ceriotti
Jun 26, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Mattias AldrimerDan Hellberg
Sep 28, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Linda HilstedAnders Juul
Feb 14, 2013·Primary Care·Robert H Nelson

❮ Previous
Next ❯

Citations

Dec 4, 2019·Acta Neuropsychiatrica·Katrin Tomson-JohansonJaanus Harro
Feb 2, 2020·Lipids in Health and Disease·Fatemeh Azizi-SoleimanRoya Kelishadi
Apr 29, 2020·Sports·Asgeir MamenPer Morten Fredriksen

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02495714

Software Mentioned

Generalized Additive Models for Location Scale and Shape ( GAM...
R
EQUALIS
RefVal

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.