Reference limits of serum TSH and free T4 are significantly influenced by race and age in an urban outpatient medical practice

Clinical Endocrinology
Laura Boucai, Martin I Surks

Abstract

The suitability of TSH reference limits derived from national databases to outpatient practices has not been established. We aimed to determine whether race and age influence the distribution of TSH and free T4 (fT4). A cross-sectional study of an urban outpatient medical practice. Patients (n = 22,116) without clinical evidence of thyroid disease or use of thyroid-specific medications. Comparison of TSH and fT4 distributions in specific racial and age groups including blacks, whites and Hispanics. TSH was distributed at higher concentrations, without skew, in whites compared to blacks (median, 1.54 mIU/l vs. 1.18 mIU/l, P < 0.001) and in old (>80 years old) compared to young (20-29 years old) (median, 1.61 mIU/l vs. 1.13 mIU/l, P < 0.001). In all patients, blacks and whites, 3%, 8% and 5%, respectively, of those aged > 80 years were misclassified as having high TSH compared to those aged 20-29 years (P < 0.001). Using TSH limits from national databases resulted in significant misclassification of patients with raised or lowered TSH. Mean fT4 was significantly lower in blacks than whites (17.5 +/- 4.38 pmol/l vs. 18.3 +/- 3.99 pmol/l, P < 0.001), did not differ between young and old, but decreased progressively (average 7%) as ...Continue Reading

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