Reference markers of bone turnover for prediction of fracture: a meta-analysis

Journal of Orthopaedic Surgery and Research
Aixian TianXinlong Ma

Abstract

To explore whether bone turnover biomarkers (BTMs), i.e., C-terminal telopeptide of type I collagen (CTX) and procollagen type I aminoterminal propeptide (PINP), are associated with fracture. We searched electronic database including PubMed, Embase and Cochrane Library, and the reference lists of relevant articles published from inception to August 22, 2018. An updated meta-analysis was performed to assess the prediction value of CTX and PINP in fracture. Nine articles met our inclusion criteria and were included in the meta-analysis. The crude and adjusted effect size between PINP and fracture were extracted from two and five studies, respectively. PINP was not associated with fracture incidence without adjusting covariates (crude GR, 1.03; 95% CI, 0.91-1.17). After adjusting for potential confounders, PINP demonstrated a significant positive association with fracture (adjusted GR, 1.28; 95% CI, 1.15-1.42). In the subgroup analysis of studies after adjusting covariates, there were significant associations in women. Both the crude (1.16, 95%CI, 1.04-1.20) and adjusted GR (1.20, 95%CI, 1.05-1.37) shown positive relationships between CTX and fracture, which were extracted from four and six studies, separately. The sensitivity ana...Continue Reading

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Citations

Jul 28, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicola NapoliAnn V Schwartz
Jan 12, 2021·Calcified Tissue International·K Kerschan-SchindlP Pietschmann
Jan 23, 2021·Journal of Orthopaedic Surgery·Zhongxin ZhuXiaocong Yao
Apr 3, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Stefano FraraAndrea Giustina
Mar 24, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·J-M PouillèsF Trémollieres
May 20, 2021·Journal of Orthopaedic Surgery and Research·Filippo MiglioriniGiorgino Riccardo
May 24, 2021·Endocrinology and Metabolism Clinics of North America·Sumeet Jain
Oct 12, 2021·Experimental and Therapeutic Medicine·Vlad PopAnca Bojan
Aug 26, 2021·Medicine and Science in Sports and Exercise·Julie AbildgaardMathias Ried-Larsen
Sep 22, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sara GanhãoCarlos Vaz

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