PMID: 7539558Jun 1, 1995Paper

Reference range for prostate-specific antigen levels after external beam radiation therapy for adenocarcinoma of the prostate

Urology
R W Geist

Abstract

To determine a reference range for prostate-specific antigen (PSA) in patients who have had external beam radiation therapy for adenocarcinoma of the prostate. Serum PSA levels were serially measured with the Hybritech Tandem-R assay in 35 patients who had completed radiation therapy for a mean of 51 +/- 32 months (range, 10 to 133). Serum PSA levels that were greater than 2.0 ng/mL (n = 20) continued to rise at a rate of more than 1 ng/mL per year, whereas levels between 0.0 and 2.0 ng/mL (n = 15) remained stable for an average of 71 +/- 32 months (range, 22 to 133). One of these latter 15 patients had a false-negative PSA level when he experienced a biopsy-positive prostate nodule and positive bone scan 43 months after therapy. Prostate cancer control after radiation therapy was indicated in most men by a PSA reference range of 0.0 to 2.0 ng/mL. Cancer activity was indicated in all men with levels above this range.

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Citations

Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stephen A MangarAlan Horwich
Mar 1, 1997·Urology·P R CarrollM Roach
Nov 1, 1996·The Urologic Clinics of North America·D A CorralA C von Eschenbach
Oct 13, 2006·Current Opinion in Urology·F Parivar, J Kurhanewicz
May 1, 1997·The Urologic Clinics of North America·J A ConnollyP R Carroll
Nov 20, 1997·The Journal of Urology·K ShinoharaP R Carroll
May 1, 1997·The Urologic Clinics of North America·P F SchellhammerG L Wright

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