Reference Ranges and Determinants of Tricuspid Regurgitation Velocity in Healthy Adults Assessed by Two-Dimensional Doppler-Echocardiography

Respiration; International Review of Thoracic Diseases
Alberto M MarraEduardo Bossone

Abstract

Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). To explore the physiologic range of TRV in healthy adults and to investigate its clinical determinants. In the first part of the study, 614 healthy individuals (age 45.7± 14.7 years, 60.26% women) were prospectively assessed by TTE. In the second part, a pooled meta-analysis of 16 already published studies with TRV values in healthy subjects (n = 981) was performed. Statistical analysis included the calculation of 95% quantiles for defining reference ranges. In the prospectively enrolled cohort, mean TRV was 2.01 ± 0.29 m/s (5-95% CI 1.987-2.033 m/s). It was significantly but weakly positively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, left atrial volume and negative with mitral inflow E/A ratio. No significant differences were found between males and females. The prospectively enrolled data revealed similar values to the literature-based datasets resulting in a mean TRV of 1.96 m/s (95% CI 1.91-2.02 m/s) and a 95% quantile of 2.55 m/s. To the best of our knowledge, this is the largest dataset to de...Continue Reading

Citations

May 29, 2020·The International Journal of Cardiovascular Imaging·Karina Wierzbowska-DrabikEugenio Picano
May 21, 2020·The European Respiratory Journal·Mona LichtblauSilvia Ulrich
Mar 5, 2019·Current Cardiology Reports·Francesco FerraraEduardo Bossone

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