Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by TurboFlow-LC-MS/MS and associations to health markers in 304 men

Clinica Chimica Acta; International Journal of Clinical Chemistry
A Damgaard-OlesenA Juul

Abstract

We report reference ranges based on LC-MS/MS for testosterone (T), free testosterone (FT) and its precursors, i.e. 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEAS) and androstenedione (Adione), in relation to different health markers and lifestyle factors. The study was based on 304 healthy men aged 30-61 years participating in a population-based cross-sectional study (Health2008). Examination program consisted of a clinical examination, completion of a self-administered questionnaire and blood sampling. Steroid metabolites were measured by a validated and sensitive LC-MS/MS method. Older age-groups were significantly associated with decreased concentrations of DHEA, DHEAS, Adione, and FT, while no significant associations with age were shown for 17-OHP or T. Participants with BMI≥30 kg/m(2) had lower age-related steroid metabolite z-scores compared to participants with BMI<30 kg/m(2), i.e. 17-OHP: -0.51 vs. 0.08 (p<0.001); DHEA: -0.27 vs. 0.09 (p=0.014); Adione: -0.29 vs. 0.09 (p=0.012); T: -0.99 vs. 0.14 (p<0.001); and FT -0.55 vs. 0.05 (p<0.001), respectively. In conclusion, this large study on serum steroid metabolites and concomitant assessment of health markers in healthy men provides a...Continue Reading

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Citations

Jun 1, 2016·Scientific Reports·Marieke van der HeidenAnne-Marie Buisman
Jun 2, 2017·European Journal of Endocrinology·Lina SchifferMichael W O'Reilly
Apr 30, 2019·Endocrine Connections·M P SchuijtA E van Herwaarden
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Mar 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Jakob AlbrethsenAnders Juul
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Nanna KolbyAnders Juul
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Dec 3, 2020·Journal of Clinical Medicine·José Ignacio Martínez-MontoroJosé Carlos Fernández-García

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