Reference ranges of serum bile acids in children and adolescents

Clinical Chemistry and Laboratory Medicine : CCLM
Jörg JahnelTatjana Stojakovic

Abstract

Bile acids (BA) are found predominantly in bile but also in serum, where they can be used as markers for inborn and acquired hepatobiliary disorders. We measured serum BA levels by mass spectrometry to determine reference ranges for healthy children and adolescents in different age groups. In 194 healthy children and adolescents (0-19 years) concentrations of serum BA and BA composition were determined using high-performance liquid chromatography high-resolution mass spectrometry. Individuals were classified by ages into five groups: 0-5 months, 6-24 months, 3-5 years, 6-11 years, and >11 years. The 95% confidence interval of serum total BA values in newborns was 3.85-6.32 μmol/L. In the cohort aged 6-24 months total BA values were significantly higher (6.61-9.43 μmol/L; p<0.001). During growth, values decreased (6-11 years; 3.61-5.41 μmol/L), and after 11 years (3.09-4.12 μmol/L) resembled those in adults (0.28-6.50 μmol/L). With respect to conjugation patterns, in neonates BA were primarily conjugated with taurine; however, after 6 months glycine conjugates clearly predominated. Our data show that serum BA values vary substantially during the first years of life and that reference ranges for BA are age-dependent. The physiolo...Continue Reading

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Citations

Nov 14, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Benno AmplatzGünter Fauler
Jun 21, 2016·Journal of Pediatric Gastroenterology and Nutrition·Richard D SembaMark J Manary
Sep 16, 2020·Scientific Reports·Masaru TanakaJiro Nakayama
Jun 12, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Xinying HongMichael H Gelb
Nov 20, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Katharina HablerMichael Vogeser

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