Reference tissue normalization in longitudinal (18)F-florbetapir positron emission tomography of late mild cognitive impairment

Alzheimer's Research & Therapy
Sepideh ShokouhiAlzheimer’s Disease Neuroimaging Initiative

Abstract

Semiquantitative methods such as the standardized uptake value ratio (SUVR) require normalization of the radiotracer activity to a reference tissue to monitor changes in the accumulation of amyloid-β (Aβ) plaques measured with positron emission tomography (PET). The objective of this study was to evaluate the effect of reference tissue normalization in a test-retest (18)F-florbetapir SUVR study using cerebellar gray matter, white matter (two different segmentation masks), brainstem, and corpus callosum as reference regions. We calculated the correlation between (18)F-florbetapir PET and concurrent cerebrospinal fluid (CSF) Aβ1-42 levels in a late mild cognitive impairment cohort with longitudinal PET and CSF data over the course of 2 years. In addition to conventional SUVR analysis using mean and median values of normalized brain radiotracer activity, we investigated a new image analysis technique-the weighted two-point correlation function (wS2)-to capture potentially more subtle changes in Aβ-PET data. Compared with the SUVRs normalized to cerebellar gray matter, all cerebral-to-white matter normalization schemes resulted in a higher inverse correlation between PET and CSF Aβ1-42, while the brainstem normalization gave the be...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Jul 11, 2000·Nature Medicine·B V ZlokovicB Frangione
Jul 11, 2000·Nature Medicine·B V ZlokovicB Frangione
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kooresh Shoghi-JadidJorge R Barrio
Dec 3, 2003·Molecular Imaging·Andreas Markus Loening, Sanjiv Sam Gambhir
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Mar 15, 2008·Brain : a Journal of Neurology·Milos D IkonomovicSteven T DeKosky
Aug 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardJan Pruim
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanRichard J Caselli
Apr 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michel KooleKoen Van Laere
Jul 18, 2009·PloS One·Peder BuchhaveOskar Hansson
Oct 14, 2009·Neurology·W J JagustUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Seok Rye ChoiHank F Kung
Nov 3, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Koon-Pong WongSung-Cheng Huang
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·William J JagustUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 15, 2010·Science·Kwasi G MawuenyegaRandall J Bateman
Oct 11, 2011·Trends in Cognitive Sciences·William J Jagust, Elizabeth C Mormino
May 31, 2012·Brain Imaging and Behavior·Laura E GibbonsUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 31, 2012·Advances in Pharmacology·Ann D CohenMilos D Ikonomovic
Mar 16, 2013·Nature Reviews. Drug Discovery·Paul S AisenHarald Hampel
Mar 29, 2013·Annals of Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 30, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Niklas MattssonUNKNOWN Alzheimer's Association QC Program Work Group
Aug 13, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark E SchmidtUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 9, 2014·NeuroImage·Matthias BrendelUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kewei ChenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan M LandauWilliam J Jagust
May 7, 2015·Clinical Interventions in Aging·Sepideh ShokouhiUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Citations

Jun 22, 2016·Brain Pathology·Sepideh ShokouhiUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 14, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sandeep Sv GollaAdriaan A Lammertsma
Aug 29, 2019·Annals of Nuclear Medicine·Masashi KameyamaKenji Ishii
Jun 23, 2018·Frontiers in Aging Neuroscience·Fermín SegoviaManuel Gómez-Río
Apr 26, 2019·Annals of Clinical and Translational Neurology·Burcu ZeydanKejal Kantarci
Sep 27, 2018·Alzheimer's Research & Therapy·Umesh GangishettiWilliam T Hu
Apr 27, 2017·Alzheimer's Research & Therapy·Fayçal Ben BouallègueUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Sep 5, 2017·Journal of Alzheimer's Disease : JAD·Ellis NiemantsverdrietSebastiaan Engelborghs
Mar 17, 2020·Journal of Alzheimer's Disease : JAD·Ya-Juan WangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 19, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Yun ZhouTammie L S Benzinger
Mar 7, 2021·International Journal of Molecular Sciences·Wieke M van Oostveen, Elizabeth C M de Lange
Apr 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jordi PeguerolesUNKNOWN Australian Imaging, Biomarkers and Lifestyle Research Group
Apr 21, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Val J LoweClifford R Jack
Mar 25, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Julie OttoySteven Staelens
Sep 15, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan M Landau

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