Reference value for cardiac troponin I in a multi-ethnic group

Pathology
Pavai SthaneshwarYap Sook Fan

Abstract

The aim of this study was to evaluate the distribution of cardiac troponin I (cTnI) values, measured by the ADVIA TnI-Ultra method in a multi-ethnic group and to determine the imprecision of the assay. The study population comprised 234 men and 208 women and the age range was 18-73 years. Recruitment was aimed at enrolling different races and comprised 186 Malays, 136 Chinese and 120 Indians. We evaluated the analytical performance the ultra sensitive cardiac troponin I (cTnI) assay. The mean values for cTnI for male and female were 0.011 microg/L and 0.010 microg/L respectively. No significant difference was noted between male and female populations (p > 0.05). The 99th percentile for ADVIA TnI-Ultra was 0.061 microg/L. The mean values of cTn in Malay, Chinese and Indian groups were 0.011, 0.011 and 0.011 microg/L, respectively. There was no significant difference between the different ethnic populations (p > 0.05). The assay imprecision was less than 10% at concentrations higher than 0.036 microg/L. ADVIA TnI-Ultra assay showed no difference in the troponin values among different ethnic groups and between males and females. Hence a single cut-off value based on the 99th percentile can be used.

References

Aug 14, 2001·Journal of the American College of Cardiology·P A HeidenreichM A Hlatky
Aug 23, 2007·Clinical Chemistry·Concetta PronteraAldo Clerico

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Citations

Aug 21, 2012·The Journal of Emergency Medicine·Giuseppe Lippi, Gianfranco Cervellin
Jan 13, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·C M GijsbertsI E Hoefer
Nov 9, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dae-Hyun KoWon-Ki Min
May 26, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Eline P M CardinaelsMarja P van Dieijen-Visser
Jun 8, 2018·Critical Reviews in Clinical Laboratory Sciences·Houman TahmasebiKhosrow Adeli
Oct 12, 2013·Clinical Chemistry·Yader Sandoval, Fred S Apple
Mar 31, 2021·Journal of Clinical Pathology·Tejas R KalariaRousseau Gama

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