Reference values and sex differences in absolute and relative kidney size. A Swiss autopsy study.

BMC Nephrology
Sabrina Addidou KaluckiMenno Pruijm

Abstract

Men have larger kidneys than women, but it is unclear whether gender remains an independent predictor of kidney size (expressed as weight or length) after correction for body size. We analysed autopsy data to assess whether relative renal length and weight (e.g. corrected for body weight, height or body surface area (BSA)) are also larger in men. Assuming that kidney size is associated with nephron number, opposite findings could partly explain why women are less prone to the development and progression of chronic kidney disease than men. All forensic autopsies performed between 2009 and 2015 at the local university hospital of Geneva in individuals of European descent aged ≥18 years without a known history of diabetes and/or kidney disease were examined. Individuals with putrefied or severely injured bodies were excluded. Relative renal weight and length were respectively defined as renal weight divided by body weight or BSA and renal length divided by body height or BSA. A total of 635 autopsies (68.7% men) were included in the analysis. Left kidneys were on average 8 g heavier and 2 mm longer than right kidneys (both: p < 0.05). Absolute renal weight (165 ± 40 vs 122 ± 29 g) and length (12.0 ± 1.3 vs 11.4 ± 1.1 cm) were high...Continue Reading

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Citations

Jan 20, 2021·Current Opinion in Nephrology and Hypertension·Maya N Clark-CutaiaAllison Squires
Jun 3, 2021·International Journal of Molecular Sciences·Margaux LaulhéLaetitia Martinerie

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Methods Mentioned

BETA
imaging techniques
biopsy
biopsies

Software Mentioned

R
GAMLSS

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