Refined identification of neutralization-resistant HIV-1 CRF02_AG viruses.

Journal of Virology
Rajesh Abraham JacobJeffrey R Dorfman

Abstract

We studied neutralization of CRF02_AG HIV-1-infected plasma samples. In contrast to previous reports, these samples neutralized CRF02_AG viruses better than other viruses. This included six of eight CRF02_AG viruses previously designated resistant (tier 2/3 or 3). Only viruses 253-11 and 278-50 remained highly resistant, but they were sensitive to membrane-proximal external region (MPER)-specific monoclonal antibodies, suggesting neutralization targets for even these viruses. We propose using high-neutralizing-within-subtype samples for evaluation of neutralization resistance of viruses.

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Citations

Jul 21, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marcel TongoJeffrey R Dorfman
Apr 6, 2018·Journal of Virology·Thandeka MoyoJeffrey R Dorfman

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