PMID: 9541230Apr 16, 1998Paper

Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci

European Journal of Oral Sciences
M MacDougall

Abstract

Dentinogenesis imperfecta type II and dentin dysplasia type II are diseases resulting in abnormal dentin formation, which have been mapped to overlapping regions of human chromosome 4q defined by markers D4S2691 and D4S2692 (6.6 cM) and D4S3291 and SPP1 (14.1 cM), respectively. Recently, two of the major non-collagenous proteins of dentin, dentin sialoprotein (DSP) and dentin phosphoprotein (DPP, phosphophoryn) have been shown to be encoded by a single gene, termed dentin sialophosphoprotein (DSPP), which has been mapped to human chromosome 4. The purpose of this study was to perform refined mapping of DSPP related to these disease loci by gene content mapping, as well as to place the DSPP gene on the physical map of human chromosome 4 by sequence tagged site (STS) content mapping. Human genomic DSPP clones were isolated, and gene content mapping performed with specific primers for dentin matrix protein 1 (DMP1), bone sialoprotein (BSP) and osteopontin (secreted phosphoprotein 1, SPP1). STS content mapping was then performed with flanking STS markers to these dentin/bone gene loci. Our results demonstrate that the DSPP and DMP1 genes are within a maximum distance of 110 kb. Both DSPP and DMP-1 have been placed on the physical m...Continue Reading

Citations

Aug 30, 2002·International Journal of Paediatric Dentistry·K Ch HuthR Hickel
Sep 4, 2003·Connective Tissue Research·Mary MacDougall
Dec 3, 2003·Australian Dental Journal·W K Seow
Feb 28, 2008·Journal of Periodontal Research·Y Ogata
Sep 7, 2006·American Journal of Medical Genetics. Part a·Mary MacDougallAna Carolina Acevedo
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Gaoxiang Ge, Daniel S Greenspan
Dec 6, 2012·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Neeraj Malhotra, Kundabala Mala
Jun 23, 2005·Archives of Oral Biology·N Laila HuqEric C Reynolds
Aug 15, 2014·European Journal of Human Genetics : EJHG·Muriel de La Dure-MollaAriane Berdal
Dec 13, 2006·Operative Dentistry·Jacques E Nör
May 12, 2001·European Journal of Oral Sciences·C QinW T Butler
Dec 18, 2001·American Journal of Medical Genetics·P N Kantaputra
Dec 24, 2005·Journal of Dental Research·C Chaussain-MillerS Menashi
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B GanssJ Sodek
Oct 28, 2015·Journal of Dental Research·Y ChenA George
Jun 17, 1999·Journal of Dental Research·M MacDougallR J Leach
Feb 10, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Neal S FedarkoLarry W Fisher
Nov 1, 2006·Operative Dentistry·J E N R
Oct 24, 2000·The Journal of Biological Chemistry·C QinW T Butler

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