PMID: 8952961Jan 1, 1996Paper

Refined peptide HLA-B*3501 binding motif reveals differences in 9-mer to 11-mer peptide binding

Immunogenetics
C SchönbachM Takiguchi

Abstract

HLA-B*3501 is associated with subacute thyroiditis and fast progression of AIDS. An important prerequisite to investigate the T-cell recognition of HLA-B*3501-restricted antigens is the characterization of peptide-HLA-B*3501 interactions. In this study, peptide-HLA-B*3501 interactions were determined in quantitative peptide binding assays. The results were statistically analyzed to evaluate the influence of both anchor and nonanchor positions and the predictability of peptide binding. The binding data demonstrated that all anchor residues at position 2 and the C-terminus found in 9-mers functioned equally as anchors in 10-mers and 11-mers. These minimum requirements of peptide binding were refined by assessing positive and negative effects of nonanchor residues. Aliphatic hydrophobic residues at positions 3, 5, and 8 of 10-mers and position 3 of 11-mers significantly enhanced HLA-B*3501 binding. Similar effects rendered aromatic, bulky residues, acidic or polar residues of 11-mers at position 1 as well as at positions 4, 8, and 10, respectively. Negative effects were observed for residues carrying positively charged side-chains at position 7 of 11-mers. The refined HLA-B*3501 peptide binding motifs enhanced the identification o...Continue Reading

Citations

Nov 7, 1999·Tissue Antigens·N YamadaM Takiguchi
Dec 21, 2007·Journal of Pharmacological Sciences·Hiromichi Tsurui, Takuya Takahashi
Mar 16, 2007·European Journal of Immunology·Jacqueline M BurrowsScott R Burrows
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J MilesJames McCluskey

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