PMID: 8942424Dec 1, 1996Paper

Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children

The American Journal of Clinical Nutrition
S A TanumihardjoJ A Olson

Abstract

The modified-relative-dose-response (MRDR) test, which has been used extensively throughout the world for assessing vitamin A status, has been simplified. The major methodologic change resulting from the current studies in Indonesia is the use of graded standard doses of 3,4-didehydroretinyl acetate (DRA) based on the age range of the population of interest. Instead of a dose of 0.35 mumol/kg body wt, standard doses of 5.3 mumol for children younger than 6 y, 7.0 mumol for children between 6 and 12 y of age, and 8.8 mumol for adults and children > 12 y of age are suggested for field use. The acceptable time between administering the oral dose and obtaining a blood sample was validated as being 4-7 h in a group of children (n = 84) by taking two blood samples per child between 3 and 7 h after dosing with DRA. Furthermore, DRA in vitamin E-containing corn oil, with or without the addition of 4.6 mmol all-rac-alpha-tocopheryl acetate/L, was found to be stable for > or = 18 mo at 2 degrees C and at -20 degrees C, but not at 22 degrees C or at 37 degrees C. When DRA was stored in amber glass vials, stability was affected more by temperature than by exposure to room light. In keeping with earlier studies in adults, the ratio of 3,4-d...Continue Reading

Citations

Feb 16, 1999·The American Journal of Clinical Nutrition·J A Olson
Nov 8, 2002·The Journal of Nutrition·Rajiv BahlUNKNOWN WHO/CHD Immunization-Linked Vitamin A Group
Jul 1, 2011·The American Journal of Clinical Nutrition·Sherry A Tanumihardjo
Dec 18, 2013·Nutrition Journal·Seth Owusu-AgyeiSherry A Tanumihardjo
Feb 26, 2003·The American Journal of Clinical Nutrition·Frank T WieringaJos W M Van der Meer
Mar 29, 2000·The Journal of Nutrition·N E CraftK P West
Jul 19, 2006·Nutrition Journal·Augustin N ZebaHélène F Delisle
May 11, 2007·The American Journal of Clinical Nutrition·Boniphace IdindiliDavid M Schellenberg
Mar 20, 2008·Maternal & Child Nutrition·Andrew HallNilanthi de Silva
Apr 25, 2020·Experimental Biology and Medicine·Jesse SheftelSherry A Tanumihardjo
Jul 30, 2002·The American Journal of Clinical Nutrition·Guangwen TangRobert M Russell
Mar 10, 2016·Archives of public health = Archives belges de santé publique·Sam NewtonSherry A Tanumihardjo
Jan 6, 2004·The Journal of Nutrition·Sherry A Tanumihardjo
Nov 2, 2020·Advances in Nutrition·Jesse Sheftel, Sherry A Tanumihardjo

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