Apr 13, 2020

Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy.

BioRxiv : the Preprint Server for Biology
Harvey B PollardHarvey B Pollard


Influenza viruses, corona viruses and related pneumotropic viruses cause sickness and death partly by inducing a hyper-proinflammatory response by immune cells and cytokines in the host airway. Here we show that the cardiac glycoside digitoxin suppresses this response induced by influenza virus strain A/Wuhan/H3N2/359/95 in the cotton rat lung. The cytokines TNFa, GRO/KC, MIP2, MCP1, TGFb, and IFNg. are significantly reduced. Since the hyper-proinflammatory overproduction of cytokines is a host response, we suggest that digitoxin may have therapeutic potential for not only influenza and but also for coronovirus infections.

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Mentioned in this Paper

Y Chromosome
Southern Paiute Race
Chromosomes, Human, Y
Cell Growth
Genes, Y-Linked
Lactic acid dehydrogenase isoenzyme 4

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