Reflectance confocal microscopy of mucosal pigmented macules: a review of 56 cases including 10 macular melanomas

The British Journal of Dermatology
Sébastien DebarbieuxGroupe d'Imagerie Cutanée Non Invasive de la Société Française de Dermatologie

Abstract

Although most mucosal pigmented macules are benign, it can be clinically challenging to rule out an early melanoma. Reflectance confocal microscopy (RCM) is a noninvasive imaging technique useful in discriminating between benign and malignant skin lesions. To describe the confocal aspects of benign and malignant mucosal pigmented macules with histopathological correlations. We retrospectively reviewed the confocal images of 56 labial or genital pigmented macules including 10 macular melanomas. According to the retrospective nature of the study, we evaluated the recorded images chosen by the physicians that performed the RCM examination for each case. In benign macules, the most frequently observed pattern was a ringed pattern characterized by round or polycyclic papillae, with a hyper-reflective basal layer; another pattern was characterized by sparse bright dendritic cells in the basal layer, the basal epithelial cells being otherwise less reflective. Roundish cells, a high density of dendritic cells with atypias and intraepithelial bright cells were clues to the presence of malignancy. Reflectance confocal microscopy seems to be a valuable tool to noninvasively differentiate benign from malignant mucosal pigmented macules and...Continue Reading

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Citations

Feb 21, 2016·Annales de dermatologie et de vénéréologie·S DebarbieuxUNKNOWN groupe Imagerie cutanée non invasive de la Société française de dermatologie
Jun 9, 2015·Journal of the American Academy of Dermatology·Syril Keena T QueAlon Scope
Oct 11, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Nigel G MaherPascale Guitera
Oct 4, 2016·Dermatologic Clinics·Caterina Longo, Giovanni Pellacani
Feb 6, 2017·Journal of Lower Genital Tract Disease·Francisco E RoblesMaria Angelica Selim
Jun 20, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C TheillacS Debarbieux
May 31, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·E De PianoP Rubegni
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Apr 22, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Martin LaimerVerena Ahlgrimm-Siess
Dec 30, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·E CinottiF Cambazard
Oct 3, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·E CinottiUNKNOWN Groupe Imagerie Cutanée Non Invasive de la Société Française de Dermatologie
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