Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries

American Journal of Physiology. Heart and Circulatory Physiology
John G SledChristopher K Macgowan

Abstract

The pulsatile pattern of blood motion measured by Doppler ultrasound within the umbilical artery is known to contain useful diagnostic information and is widely used to monitor pregnancies at risk of fetal growth restriction or stillbirth. Animal studies have identified reflected pressure waves traveling counter to the direction of blood flow as an important factor in the shape of these waveforms. In the present study, we establish a method to measure reflected waves in the human umbilical artery and assess their influence on blood velocity pulsation. Ninety-five pregnant women were recruited from a general obstetrics clinic between 26 and 37 wk of gestation and examined by Doppler ultrasound. Blood velocity waveforms were recorded for each umbilical artery at three locations along the umbilical cord. With the use of a computational procedure, a pair of forward and reverse propagating waves was identified to explain the variation in observed Doppler ultrasound waveforms along the cord. Among the data sets that met data quality requirements, waveforms in 93 of the 130 arteries examined agreed with the wave reflection model to within 1.5% and showed reflections ranging in magnitude from 3 to 52% of the forward wave amplitude. Str...Continue Reading

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Citations

Feb 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Nathaniel BakerHarvey Ho
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Harvey HoPeter Hunter

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