Reflecting on Concepts Relevant to Contemplating the Relationships Between Glucose-Insulin Perturbations, Nutrition, and Aging

Journal of the American College of Nutrition
Harry G PreussDallas Clouatre

Abstract

Background: Medical professionals attribute a crucial role in the development of several age-related, chronic health maladies to glucose-insulin perturbations - particularly, discernible insulin resistance (IR). However, little information is available concerning the degree to which relatively minor changes in IR participate over time in overall aging population, e.g., when circulating glucose and/or insulin concentrations are consistently within the higher end of normally accepted ranges. Objective: Obtaining precise knowledge is important, because proper nutritional management has the distinct capability of ameliorating the consequences. Methods: Five key concepts are suggested to underpin current thinking as to the applicable mechanisms and these are (1) the practical use of fasting blood glucose (FBG) levels as an estimate of IR, (2) the potential role of even slightly aberrant insulin regulation over time in the aging process, (3) the implementation of "continuum of risks" rather than checkpoints in considering prevention, (4) the presence and meaning of an aging paradox discovered in a recent study, and (5) the importance nutritional considerations in the "deadly triangle" as key factors in aging. Conclusions: Maintaining...Continue Reading

References

Nov 1, 1992·Journal of Gerontology·E J MasoroC A McMahan
Jan 1, 1990·Journal of Cardiovascular Pharmacology·E FerranniniM P Stern
Jan 1, 1991·Diabetes·H ShimokataR Andres
Aug 1, 1989·Hypertension·G M ReavenB B Hoffmann
Aug 1, 1989·Journal of the American Geriatrics Society·G M ReavenY D Chen
Feb 6, 1971·British Medical Journal·J Yudkin, S Szanto
May 1, 1967·The American Journal of Clinical Nutrition·J Yudin, J Morland
Jun 1, 1983·The Journal of Clinical Investigation·R I FinkJ M Olefsky
Jul 1, 1981·Diabetes Care·R A DeFronzo
Oct 10, 1997·Journal of the American College of Nutrition·H G Preuss
Oct 10, 1997·Journal of the American College of Nutrition·H G Preuss
Feb 27, 1998·Journal of the American College of Nutrition·H G PreussJ Knapka
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pouneh MofradArun J Sanyal
Jan 1, 1964·The Proceedings of the Nutrition Society·J YUDKIN
Nov 18, 2003·Biogerontology·Vladimir N AnisimovAnatoli I Yashin
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Dec 21, 2010·PloS One·Mamie H DongRohit Loomba
Sep 21, 2011·Journal of Inorganic Biochemistry·Harry G PreussNicholas V Perricone
Oct 25, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mamie H DongRohit Loomba
Aug 1, 2013·Nature Communications·Alejandro Martin-MontalvoRafael de Cabo
Sep 13, 2017·Journal of the American College of Nutrition·Harry G PreussGilbert R Kaats
Nov 22, 2017·JAMA : the Journal of the American Medical Association·Paul K Whelton, Robert M Carey

❮ Previous
Next ❯

Citations

Dec 13, 2019·Oncotarget·Alexey G Golubev, Vladimir N Anisimov
Jul 4, 2020·Journal of the American College of Nutrition·Harry G Preuss, Okezie I Aruoma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Health Services Manager
S H Appelbaum
Medical World
A ABRAHAMS
Canadian Medical Association Journal
C Hunter
© 2022 Meta ULC. All rights reserved