Reflection of Cardioprotection by Remote Ischemic Perconditioning in Attenuated ST-Segment Elevation During Ongoing Coronary Occlusion in Pigs: Evidence for Cardioprotection From Ischemic Injury

Circulation Research
Petra KleinbongardGerd Heusch

Abstract

Reduction of infarct size by remote ischemic perconditioning (perRIC) is evident only after several hours reperfusion. To develop a potential real-time estimate of cardioprotection by perRIC, we have analyzed the time course of ST-segment elevation. Anesthetized open-chest pigs were subjected to 60-minute coronary occlusion and 180-minute reperfusion (placebo; n=19). PerRIC (n=18; 4×5 min/5 min hindlimb occlusion/reperfusion) was induced 20 minutes after coronary occlusion. Regional myocardial blood flow was measured with microspheres, areas of no-reflow with thioflavin-S, area at risk with blue dye, and infarct size with triphenyl tetrazolium chloride staining. Phosphorylation of protein kinase B α/β/γ, extracellular signal-regulated kinase 1/2, and signal transducer and activator of transcription 3 was determined by Western blot. ST-segment elevation was analyzed in a V2-like ECG-lead at baseline, 5- and 55-minute coronary occlusion, and 10-, 30-, 60-, and 120-minute reperfusion. Transmural blood flow at 5-minute coronary occlusion was not different between perRIC (0.029±0.015 mL/min per gram; mean±SD) and placebo (0.024±0.018 mL/min per gram) as was area at risk (perRIC: 24±6% of the left ventricle; placebo: 21±4%). Areas of...Continue Reading

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Citations

Mar 24, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Andreas SkyschallyGerd Heusch
Apr 14, 2018·Circulation Research·Xavier Rossello, Borja Ibanez
Nov 14, 2018·European Heart Journal. Acute Cardiovascular Care·Kirian van der WegAnton Pm Gorgels
Jun 8, 2019·European Heart Journal. Acute Cardiovascular Care·Xavier RosselloBorja Ibanez
Jun 27, 2018·European Heart Journal·Manuel Lobo, Borja Ibanez
Jul 6, 2020·Nature Reviews. Cardiology·Gerd Heusch
Apr 3, 2019·Basic Research in Cardiology·Georgios AmanakisAndreas Skyschally
Oct 30, 2018·Journal of the American Heart Association·Petra KleinbongardGerd Heusch
Oct 22, 2019·Pflügers Archiv : European journal of physiology·Helmut Raphael LiederPetra Kleinbongard
Aug 5, 2020·Basic Research in Cardiology·Petra Kleinbongard
Aug 19, 2018·Basic Research in Cardiology·Hans Erik BøtkerGerd Heusch
Oct 26, 2018·Circulation Research·Helmut Raphael LiederGerd Heusch
Dec 12, 2019·Drug Development Research·Natalia V NaryzhnayaPeter R Oeltgen
Aug 5, 2020·Basic Research in Cardiology·Manuel Lobo-GonzalezBorja Ibanez
Oct 16, 2020·Basic Research in Cardiology·M V BasalayS M Davidson
Feb 26, 2021·Scientific Reports·Esben Søvsø Szocska HansenWon Yong Kim
Feb 26, 2021·Basic Research in Cardiology·Lucie PearceDerek M Yellon

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