Reflections about Osteoarthritis and Curcuma longa

Pharmacognosy Reviews
Marina Cristina AkuriElen Landgraf Guiguer

Abstract

Osteoarthritis (OA) is a chronic inflammatory degenerative process that affects joints such as the hands, hips, shoulders, feet, spine, and especially knees in millions of people worldwide. Some authors have shown that Curcuma longa components may exhibit benefic effects in the treatment of degenerative diseases as OA. This plant belongs to the family Zingiberaceae and it is popularly known as turmeric or saffron. This review intended to perform a retrospective search to identify studies involving humans and animal models. This review was based on articles linking OA and C. longa. Databases as Medline, Science Direct, and Lilacs were consulted and a retrospective search was carried out in order to identify studies involving humans and animal models. The curcuminoids from C. longa exhibit actions at different locations in the pathogenesis of OA once it may play an important role as anti-inflammatory, down-regulating enzymes as phospholipase A2, cyclooxygenase-2, and lipoxygenases, and reducing tumor necrosis factor-alpha-and interleukins such as interleukin-1β (IL-1β), IL-6, and IL-8. They also act as inducer of apoptosis in synoviocytes, decreasing the inflammation process and may also reduce the synthesis of reactive oxygen sp...Continue Reading

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Citations

Jun 30, 2018·Journal of Medicinal Food·Rafaela MazieiroRicardo de Alvares Goulart
Oct 14, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yufeng SunShan Jiang
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Feb 2, 2021·Clinical and Experimental Dermatology·S M BarbalhoB de Alvarez Rezende
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Sep 10, 2021·Pain Practice : the Official Journal of World Institute of Pain·Nicoletta MarchesiMassimo Allegri

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