Reflections on chemical modification of proteinases and their protein inhibitors

Biochimie
R E Feeney

Abstract

Proteolytic enzymes and their protein inhibitors have been studied by chemical modification for over four decades. Modifications have helped to identify the active (and reactive) sites and to understand their mechanisms of interaction. Inactive derivatives of the enzymes form stable complexes with some inhibitors. These inactive enzymes have also been used for affinity chromatographic adsorptions.

References

Jan 5, 1987·Journal of Molecular Biology·A WlodawerR Huber
Jul 1, 1985·International Journal of Peptide and Protein Research·W S WongR E Feeney
Feb 1, 1987·International Journal of Peptide and Protein Research·R E Feeney
Nov 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·K E Neet, D E Koshland
Mar 20, 1968·Archives of Biochemistry and Biophysics·D T Osuga, R E Feeney
Jan 1, 1966·Archives of Biochemistry and Biophysics·M M Simlot, R E Feeney
Aug 12, 1966·Biochemical and Biophysical Research Communications·G FeinsteinR E Feeney
Feb 1, 1967·Biochemistry·R HaynesR E Feeney
Oct 1, 1954·Archives of Biochemistry and Biophysics·J S RAMF F NORD
Jan 1, 1954·Advances in Protein Chemistry·M LASKOWSKI, M LASKOWSKI
Nov 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·D H STRUMEYERD E KOSHLAND
Nov 1, 1963·Biochemistry·F C STEVENS, R E FEENEY

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