Reflections on the mechanism(s) of action of sodium cromoglycate (Intal) and the role of mast cells in asthma
In this review, only a few questions concerning the mechanism(s) of action of sodium cromoglycate in asthma have been considered. The large number of cells and mediator pathways where sodium cromoglycate may have pharmacological effects are depicted. In addition to its mast cell effect, sodium cromoglycate is also inhibitory to macrophages, eosinophils, monocytes and platelets, which are all important components in the inflammatory response of asthma. From studies with bradykinin and sulphur dioxide it is also known that the drug can block afferent discharges along non-myelinated nerves. Although the ability of sodium cromoglycate to block late phase responses and acquired hyper-reactivity is not questioned, to what extent its therapeutic efficacy can be accounted for by actions on these leukocytes and reflex pathways is not known. When administered to patients with asthma, sodium cromoglycate results in symptomatic improvement, but there is still much to be learned about its mode of action.
Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction
Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol
Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli
Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma
Human basophil/mast cell releasability. V. Functional comparisons of cells obtained from peripheral blood, lung parenchyma, and bronchoalveolar lavage in asthmatics
Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine
Effects of two doses of cromolyn on allergen-induced late asthmatic response and increased responsiveness
The effect of cromolyn sodium and albuterol on early and late phase bronchoconstriction and airway leukocyte infiltration after allergen challenge of nonanesthetized guinea pigs
Early and late-phase bronchoconstriction after allergen challenge of nonanesthetized guinea pigs. I. The association of disordered airway physiology to leukocyte infiltration
Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness
Modification of bronchial hyperreactivity after treatment with sodium cromoglycate during pollen season
Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone
Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms
Secretion in dissociated human pulmonary mast cells. Evidence for solubilization of granule contents before discharge
The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine
Bronchoalveolar lavage in asthma: the effect of disodium cromoglycate (cromolyn) on leukocyte counts, immunoglobulins, and complement
The effect of sodium cromoglycate on upper and lower respiratory symptoms in children born prematurely
Effect of the antiallergic drug disodium cromoglycate and various derivatives on alkaline phosphatase
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.