Reflections upon human cancer immune responsiveness to T cell-based therapy.

Cancer Immunology, Immunotherapy : CII
Ena WangFrancesco M Marincola

Abstract

Immune-mediated rejection of human cancer is a relatively rare but well-documented phenomenon. Its rate of occurrence progressively increases from the occasional observation of spontaneous regressions to the high rate of complete remissions observed in response to effective treatments. For two decades, our group has focused its interest in understanding this phenomenon by studying humans following an inductive approach. Sticking to a sequential logic, we dissected the phenomenon by studying to the best of our capability both peripheral and tumor samples and reached the conclusion that immune-mediated cancer rejection is a facet of autoimmunity where the target tissue is the cancer itself. As we are currently defining the strategy to effectively identify the mechanisms leading in individual patients to rejection of their own tumors, we considered useful to summarize the thought process that guided us to our own interpretation of the mechanisms of immune responsiveness.

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Citations

Apr 3, 2014·The Journal of Clinical Investigation·Qiuzhen LiuFrancesco M Marincola
Mar 15, 2014·Expert Opinion on Biological Therapy·Sara TomeiDavide Bedognetti
May 9, 2013·Annals of the New York Academy of Sciences·Ena WangFrancesco M Marincola
Jul 6, 2016·Therapeutic Advances in Respiratory Disease·Dandan ZongPing Chen
Dec 12, 2017·Emerging Topics in Life Sciences·Sara I Pai, Lori J Wirth

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Methods Mentioned

BETA
biopsy
biopsies
MDA

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