Although "teeth clenching" induces pressor response, the reflex tracts of the response are unknown. In this study, dantrolene administration inhibited teeth clenching generated by electrical stimulation of the masseter muscles and completely abolished the pressor response. In addition, trigeminal ganglion block or hexamethonium administration completely abolished the pressor response. Local anesthesia of molar regions significantly reduced the pressor response to 27 ± 10%. Gadolinium (mechanoreceptor blocker of group III muscle afferents) entrapment in masticatory muscles also significantly reduced the pressor response to 62 ± 7%. Although atropine methyl nitrate administration did not change the pressor response, a significant dose-dependent augmentation of heart rate was observed. These results indicate that both periodontal membrane and mechanoreceptors in masticatory muscles are the receptors for the pressor response, and that the afferent and efferent pathways of the pressor response pass through the trigeminal afferent nerves and sympathetic nerves, respectively.
Effects of dantrolene sodium on respiratory and other muscles and on respiratory parameters in the anaesthetised cat
Morphological characteristics and terminating patterns of masseteric neurons of the mesencephalic trigeminal nucleus in the rat: an intracellular horseradish peroxidase labeling study
Mesencephalic trigeminal sensory neurons of cat: axon pathways and structure of mechanoreceptive endings in periodontal ligament
Gadolinium inhibits mechanoelectrical transduction in rabbit carotid baroreceptors. Implication of stretch-activated channels
Effect of mastication on regional cerebral blood flow in humans examined by positron-emission tomography with ¹⁵O-labelled water and magnetic resonance imaging
Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors.
Physiological properties of molar-mechanosensitive periodontal neurons in the trigeminal ganglion of the rat
Gadolinium does not blunt the cardiovascular responses at the onset of voluntary static exercise in cats: a predominant role of central command
Muscle mechanosensitive receptors close to the myotendinous junction of the Achilles tendon elicit a pressor reflex
Response properties of periodontal mechanosensitive neurons in the trigeminal ganglion of rabbit and neuronal activities during grinding-like jaw movement induced by cortical stimulation
Functional near-infrared spectroscopy study on primary motor and sensory cortex response to clenching
Pressor responses to isometric biting are evoked by somatosensory receptors in periodontal tissue in humans
Effect of mastication on functional recoveries after permanent middle cerebral artery occlusion in rats
Water drinking-related muscle contraction induces the pressor response via mechanoreceptors in conscious rats
Impaired baroreflex function is related to reduced carotid artery elasticity in patients with tetralogy of Fallot
High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons
Improvement of baroreflex sensitivity in patients with obstructive sleep apnea following surgical treatment
Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity
Involvement of the basal nucleus of Meynert on regional cerebral cortical vasodilation associated with masticatory muscle activity in rats.
Blood pressure-independent increase in the cortical cerebral blood flow induced by manual acupuncture of the auricular region in rats
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