Reflex control of sympathetic activity during ventricular tachycardia in dogs: primary role of arterial baroreflexes

Circulation
M L SmithM E Dibner-Dunlap

Abstract

The determinants of hemodynamic outcome during ventricular tachycardia (VT) are not well understood. In the present study, we addressed the relative contributions of arterial and cardiopulmonary baroreflexes to the sympathetic and arterial pressure responses to VT or ventricular pacing (VP) in dogs with inducible VT. Responses of renal sympathetic nerve activity (RSNA), pulmonary capillary wedge pressure (PCWP), and mean arterial pressure (MAP) to induced VT or VP (220 to 280 beats per minute) were determined in 12 dogs with a healed anteroapical infarction and inducible VT and in 8 control dogs. The responses were determined with all reflexes intact, after selective denervation of either arterial or cardiopulmonary baroreflexes, and after combined denervation. Differences between intact and denervated conditions were used to assess the relative effects of each baroreflex. In the infarct group, responses during VT were comparable to those during VP. RSNA and PCWP increased significantly (P<.01), whereas MAP decreased significantly (P<.001) during VT or VP with baroreflexes intact in both groups. The increase in RSNA and the recovery of MAP during sustained VP were greater in the infarct group (P<.05); in addition, the increase ...Continue Reading

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Citations

Nov 28, 2012·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M T La RovereP Sleight
Mar 1, 1997·Journal of the American College of Cardiology·M LandolinaG M De Ferrari
May 13, 2005·The New England Journal of Medicine·Xavier JouvenPierre Ducimetière
Nov 26, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Stephen L WasmundMohamed H Hamdan
Oct 6, 2004·Pacing and Clinical Electrophysiology : PACE·Michael O Sweeney
May 23, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Maria Teresa La Rovere, Gian Domenico Pinna
Jun 19, 2007·Orvosi hetilap·Tamás Szili-TörökLászló Rudas
Mar 21, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Javier Jiménez-CandilPedro Luis Sánchez

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