Reflex effects and postsynaptic membrane potential changes during epileptiform activity induced by penicillin in decapitate spinal cords

Electroencephalography and Clinical Neurophysiology
E W Lothman, G G Somjen

Abstract

The administration of a convulsant dose of penicillin enhanced the transmission of monosynaptic reflexes in spinal cords in which reflex transmission was feeble before the drug treatment, but it had little effect in cords where monosynaptic reflexes were powerful to begin with. Post-tetanic potentiation was not altered by penicillin. Polysynaptic reflexes were invariably enhanced by convulsant amounts of penicillin. Postsynaptic ("direct") inhibition was not affected in the seizure-free intervals in spinal cords treated with penicillin, but it seemed to be suppressed during tonic seizures. The disability of reflex inhibition during ictal discharges may be due to presynaptic depolarization of inhibitory terminals. Recurrent inhibition was partially suppressed in spinal cords treated with penicillin. Neurons in the dorsal and intermediate gray matter were sometimes excited, sometimes inhibited, and sometimes unaffected by seizure activity of their segment. Motoneurons in the ventral horns invariably participated in the interictal and ictal activity. The timing of clonic seizure sequences coincided with bursts of Renshaw cell discharges. Action potential of abnormal amplitude and configuration were frequently observed in convulsin...Continue Reading

References

Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Nov 1, 1971·Electroencephalography and Clinical Neurophysiology·D A Prince
Jul 1, 1972·Electroencephalography and Clinical Neurophysiology·G F Ayala, C Vasconetto
Oct 27, 1972·Brain Research·R A Davidoff
May 31, 1974·Brain Research·W A Wilson, A V Escueta
Aug 1, 1968·Experimental Neurology·D A Prince
May 1, 1966·Experimental Neurology·G G Somjen, C J Health
Dec 29, 1955·The Journal of Physiology·K FRANK, M G FUORTES
Sep 1, 1964·Electroencephalography and Clinical Neurophysiology·H MATSUMOTO

❮ Previous
Next ❯

Citations

Aug 1, 1979·Annals of Neurology·R C Collins, T V Caston
May 18, 1979·Brain Research·R Dingledine, L Gjerstad
Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·E W Lothman, G G Somjen
Jul 1, 1977·Experimental Neurology·J DavenportW E Crill
May 14, 1984·Brain Research·J YuW P Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.