Reflex pathways controlling urethral striated and smooth muscle function in the male rat

The American Journal of Physiology
H KakizakiW C De Groat

Abstract

The organization of vesicourethral reflex mechanisms in the male rat was studied by monitoring intraurethral pressure and the external urethral sphincter (EUS) electromyogram. EUS striated and urethral smooth muscle activities were elicited by reflex isovolumetric bladder contractions evoked by bladder filling or electrical stimulation of nerves in the bladder wall. Evoked EUS bursting activity in normal rats was eliminated in chronic spinal rats and replaced by tonic activity. Reflex urethral smooth muscle activity mediated by an increase in urethral pressure after paralysis of the EUS with alpha-bungarotoxin occurred in normal and chronic spinal rats. The response was significantly larger in chronic spinal (21.3 +/- 3.0 cmH2O) than in normal rats (4.2 +/- 0.7 cmH2O). NG-nitro-L-arginine methyl ester (a nitric oxide synthase inhibitor, 20 mg/kg i.v.) increased the smooth muscle response in normal (5.9 +/- 1.3 cmH2O) and chronic spinal rats (6.9 +/- 1.8 cmH2O). This increase in urethral pressure was not changed by sympathetic nerve transection or prazosin (0.2-0.3 mg/kg i.v.) but was abolished by hexamethonium and reduced 74-89% by atropine. These results indicate that coordinated EUS function (bursting activity) in the male ra...Continue Reading

Citations

Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S KanieM Namiki
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H KakizakiW C De Groat
Mar 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Akira FurutaNaoki Yoshimura
Sep 21, 2013·American Journal of Physiology. Renal Physiology·Wen-Jia FanChih-Wei Peng
Jul 6, 2014·American Journal of Physiology. Renal Physiology·Brandon K LaPalloJonathan S Carp
Dec 31, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P LluelS Palea
Feb 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui-Yi ChangWilliam C de Groat
Apr 15, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shih-Ching ChenChih-Wei Peng
Sep 9, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hirokazu IshidaOsamu Yokoyama
Apr 21, 2020·American Journal of Physiology. Renal Physiology·Christopher L LangdaleWarren M Grill
Sep 25, 2003·American Journal of Physiology. Renal Physiology·Ron J JankowskiDavid A Vorp
Oct 22, 2010·American Journal of Physiology. Renal Physiology·Paul H Ratz
May 5, 2020·American Journal of Physiology. Renal Physiology·Arezoo Geramipour, Zachary Danziger
Oct 30, 2009·American Journal of Physiology. Renal Physiology·Zhongguang YangMatthew O Fraser
Jan 20, 2021·Physiological Reports·Daniel Medina-AguinagaCharles H Hubscher

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