Reflex regulation of flow resistance in the feline sphincter of Oddi by hydrostatic pressure in the biliary tract

Gastroenterology
A ThuneJ Svanvik

Abstract

Despite wide variations in bile secretion and biliary tract capacitance, the pressure in the bile ducts is fairly constant. Recent studies have demonstrated that both inhibitory and excitatory nerves regulate the activity of the sphincter of Oddi. In the present study, it was consistently found that the resistance by the choledochoduodenal junction to a constant flow, within the physiologic range of hepatic bile output, is reduced when the hydrostatic pressure in the gallbladder and bile ducts is increased from 0 to 10, 0 to 15, and 0 to 20 cmH2O. This response was eliminated by tetrodotoxin or infiltration of the junction between the common bile duct and the cystic duct by mepivacaine, a local anesthetic. The results suggest a homeostatic mechanism during the interprandial periods, when the activity of the sphincter of Oddi is regulated by the distending pressure in the biliary tract. This reflex regulation is mediated by modulation of the activity of inhibitory nerves running along the common bile duct.

Citations

Sep 26, 2003·Pancreas·Per SandstromJoar Svanvik
Oct 1, 1991·Digestive Diseases and Sciences·A ThuneJ Toouli
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·P Funch-Jensen, N Ebbehøj
Jul 1, 1995·Scandinavian Journal of Gastroenterology·A ThuneJ Svanvik
Sep 1, 1991·Scandinavian Journal of Gastroenterology·P G FarupJ K Tholfsen
Mar 20, 2002·Current Gastroenterology Reports·Alexander Craig, James Toouli
Jul 1, 1990·The British Journal of Surgery·J Toouli
May 24, 2006·World Journal of Gastroenterology : WJG·Peter Funch-JensenLászló Madácsy
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C M WoodsG T P Saccone
May 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·K OkazakiY Yamamoto

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